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 Indian J Med Microbiol  
 

Figure 5: Mode of inheritance of the COL4A1 pathogenic allele. Black line indicates COL4A1 wild type allele while the line with a black star in the middle indicates allele with c1537G>A mutation. In the first cycle, 3 embryos were generated from 14 donor eggs, and all were found to harbor the pathogenic COL4A1 allele. In the second cycle, 23 donor eggs generated 12 embryos where 9 were found to harbor the pathogenic COL4A1 allele while 3 harboring only wild-type alleles. One of these three embryos with a pair of normal, wild type alleles for COL4A1 was identified for implantation. As is evident, there is no scope of any embryo which is homozygous for the pathogenic COL4A1 allele since the mother does not harbor this allele

Figure 5: Mode of inheritance of the COL4A1 pathogenic allele. Black line indicates COL4A1 wild type allele while the line with a black star in the middle indicates allele with c1537G>A mutation. In the first cycle, 3 embryos were generated from 14 donor eggs, and all were found to harbor the pathogenic COL4A1 allele. In the second cycle, 23 donor eggs generated 12 embryos where 9 were found to harbor the pathogenic COL4A1 allele while 3 harboring only wild-type alleles. One of these three embryos with a pair of normal, wild type alleles for COL4A1 was identified for implantation. As is evident, there is no scope of any embryo which is homozygous for the pathogenic COL4A1 allele since the mother does not harbor this allele