Journal of Human Reproductive Sciences

LETTER TO EDITOR
Year
: 2021  |  Volume : 14  |  Issue : 3  |  Page : 325-

Do basal luteinizing hormone and luteinizing hormone/follicle-stimulating hormone ratio have significance in prognosticating the outcome of In vitro fertilization cycles in polycystic ovary syndrome?


Pathum Sookaromdee1, Viroj Wiwanitkit2,  
1 Private Academic Consultant Center, Bangkok, Thailand
2 Department of Community Medicine, Dr. DY Patil University, Pune, Maharashtra, India

Correspondence Address:
Dr. Pathum Sookaromdee
Private Academic Consultant, Bangkok
Thailand




How to cite this article:
Sookaromdee P, Wiwanitkit V. Do basal luteinizing hormone and luteinizing hormone/follicle-stimulating hormone ratio have significance in prognosticating the outcome of In vitro fertilization cycles in polycystic ovary syndrome?.J Hum Reprod Sci 2021;14:325-325


How to cite this URL:
Sookaromdee P, Wiwanitkit V. Do basal luteinizing hormone and luteinizing hormone/follicle-stimulating hormone ratio have significance in prognosticating the outcome of In vitro fertilization cycles in polycystic ovary syndrome?. J Hum Reprod Sci [serial online] 2021 [cited 2022 Jun 28 ];14:325-325
Available from: https://www.jhrsonline.org/text.asp?2021/14/3/325/326927


Full Text



Dear Editor,

We would like to share ideas on the publication “Do basal luteinizing hormone and luteinizing hormone/follicle-stimulating hormone (LH/FSH) ratio have significance in prognosticating the outcome of in vitro fertilization (IVF) cycles in polycystic ovary syndrome?” Singh et al. noted that “The elevated basal day 2/3 LH and LH/FSH ratio do not impair the outcome of GnRH antagonist protocol treated IVF/intracytoplasmic sperm injection cycles in polycystic ovary syndrome women.[1]” Regarding the diagnostic value of basal day 2/3 LH and LH/FSH ratio, there are many confounding factors that might affect the result. First, certain genetic polymorphisms can have an effect. In a report by Deswal et al., luteinizing hormone and LH receptor gene polymorphisms played important role in determining LH and LH/FSH ratio.[2] Furthermore, assay interference might occur and result in aberrant LH and LH/FSH ratio.[3] Segal et al. reported that heterophile antibodies are examples of those interferences.[3]

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Conflicts of interest

There are no conflicts of interest.

References

1Singh N, Mishra N, Dogra Y. Do basal luteinizing hormone and luteinizing hormone/follicle-stimulating hormone ratio have significance in prognosticating the outcome of in vitro fertilization cycles in polycystic ovary syndrome? J Hum Reprod Sci 2021;14:21-7.
2Deswal R, Nanda S, Dang AS. Association of luteinizing hormone and lh receptor gene polymorphism with susceptibility of polycystic ovary syndrome. Syst Biol Reprod Med 2019;65:400-8.
3Segal DG, DiMeglio LA, Ryder KW, Vollmer PA, Pescovitz OH. Assay interference leading to misdiagnosis of central precocious puberty. Endocrine 2003;20:195-9.