Journal of Human Reproductive Sciences

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 13  |  Issue : 1  |  Page : 31--37

Autologous bone marrow-derived stem cell therapy for Asherman's syndrome and endometrial atrophy: A 5-year follow-up study


Neeta Singh1, Bhawani Shekhar1, Sujata Mohanty2, Sunesh Kumar1, Tulika Seth3, Bhavana Girish1 
1 Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Delhi, India
2 Department of Stem Cell Facility, All India Institute of Medical Sciences, Delhi, India
3 Department of Hematology, All India Institute of Medical Sciences, Delhi, India

Correspondence Address:
Dr. Neeta Singh
Department of Obstetrics and Gynaecology, Room No. 3090A, Third floor, All India Institute of Medical Sciences, Ansari Nagar,New Delhi - 110 029
India

Background: Based on the role of bone marrow (BM) stem cells in regeneration of endometrium, refractory cases of Asherman's syndrome (AS) and endometrial atrophy (EA) may benefit with BM-derived intrauterine stem cell instillation. Aims and Objectives: To evaluate the role of BM-derived autologous stem cell therapy in endometrial regeneration and restoration of menstruation and fertility in refractory cases of AS and EA. Setting: This study was conducted at a tertiary care center. Design: This was a prospective, single-arm longitudinal study. Materials and Methods: Twenty-five cases with refractory AS or EA were included. BM-derived mononuclear stem cells were instilled into the subendometrial zone followed by oral estrogen therapy for 3 months. Menstrual flow and endometrial thickness (ET) were assessed at 3, 6, and 9 months and 5 years. Results: Statistical analysis was carried out using statistical software STATA version 12.0. Mean prestem cell transfer ET (mm) was 3.3 ± 1.0. At the end of 3 months, there was a significant increase in ET (mm) to 5.1 ± 1.9 (P = 0.001), but there was no significant change at 6 months (5.6 ± 1.5; P = 0.164), at 9 months (6.1 ± 1.7; P = 0.135), or at the end of 5 years. Six of the seven amenorrheic patients resumed menses. Three patients had a successful pregnancy outcome. Conclusion: Intrauterine stem cell treatment is a promising novel approach for refractory cases of AS and EA.


How to cite this article:
Singh N, Shekhar B, Mohanty S, Kumar S, Seth T, Girish B. Autologous bone marrow-derived stem cell therapy for Asherman's syndrome and endometrial atrophy: A 5-year follow-up study.J Hum Reprod Sci 2020;13:31-37


How to cite this URL:
Singh N, Shekhar B, Mohanty S, Kumar S, Seth T, Girish B. Autologous bone marrow-derived stem cell therapy for Asherman's syndrome and endometrial atrophy: A 5-year follow-up study. J Hum Reprod Sci [serial online] 2020 [cited 2021 Jun 15 ];13:31-37
Available from: https://www.jhrsonline.org/article.asp?issn=0974-1208;year=2020;volume=13;issue=1;spage=31;epage=37;aulast=Singh;type=0