Journal of Human Reproductive Sciences

CASE REPORT
Year
: 2019  |  Volume : 12  |  Issue : 4  |  Page : 341--344

India's first child using PGT-M, PGT-A and HLA matching for helping a sibling having β-thalassemia major


Jwal M Banker1, Parul Arora1, Rajni Khajuria2, Manish Banker1 
1 NOVA IVI Fertility, Ahmedabad, Gujarat, India
2 Igenomix, New Delhi, India

Correspondence Address:
Dr. Jwal M Banker
NOVA IVI Fertility Hospital, 108 - Swastik Society, Near St. Xavier's Ladies Hostel, Navrangpura, Ahmedabad - 380 009, Gujarat
India

β-thalassemia is a common single-gene disorder in India, with hematopoietic stem cell transplantation (HSCT) being the only cure. HSCT with matched unrelated donor is less successful, whereas finding a human leukocyte antigen (HLA)-matched related donor is difficult. Preimplantation genetic testing for monogenic diseases (PGT-M) with HLA matching is a novel option to have a matched sibling for HSCT for couples having an affected child. We present the first such case report in India. A couple, both carriers of β-thalassemia and having an affected son, underwent PGT-M with HLA matching combined with preimplantation genetic testing for aneuploidies of embryos to have a β - thalassemia-free child. This resulted in birth of a 10/10 HLA-matched sibling.


How to cite this article:
Banker JM, Arora P, Khajuria R, Banker M. India's first child using PGT-M, PGT-A and HLA matching for helping a sibling having β-thalassemia major.J Hum Reprod Sci 2019;12:341-344


How to cite this URL:
Banker JM, Arora P, Khajuria R, Banker M. India's first child using PGT-M, PGT-A and HLA matching for helping a sibling having β-thalassemia major. J Hum Reprod Sci [serial online] 2019 [cited 2022 Jan 19 ];12:341-344
Available from: https://www.jhrsonline.org/article.asp?issn=0974-1208;year=2019;volume=12;issue=4;spage=341;epage=344;aulast=Banker;type=0