Journal of Human Reproductive Sciences

CASE REPORT
Year
: 2019  |  Volume : 12  |  Issue : 3  |  Page : 267--269

A rare case of swyer syndrome in two sisters with successful pregnancy outcome in both


Anupam Gupta, Ritika Bajaj, Umesh N Jindal 
 Department of Obstetrics and Gynecology, Jindal IVF and Sant Memorial Nursing Home, Chandigarh, India

Correspondence Address:
Dr. Ritika Bajaj
Jindal IVF and Sant Memorial Nursing Home, Sector 20, Chandigarh
India

Swyer syndrome is a disorder of sex development characterized by gonadal dysgenesis in a phenotypic female with normally developed Mullerian structures but a 46XY karyotype resulting from failure of testicular development in the early embryogenesis. It can have X-linked, Y-linked, or autosomal inheritance. We had a case of two sisters who presented with primary amenorrhea and primary infertility. On investigation, both had hypergonadotropic hypogonadism, 46XY karyotype, and streak gonads. They conceived following in vitro fertilization (IVF) with ovum donation. Prophylactic gonadectomy has been done in one and advised in other due to the increased risk of gonadoblastoma which is as high as 15%–35%. Such patients should be counseled that despite hypoplastic uterus, successful pregnancy can be achieved through IVF and ovum donation.


How to cite this article:
Gupta A, Bajaj R, Jindal UN. A rare case of swyer syndrome in two sisters with successful pregnancy outcome in both.J Hum Reprod Sci 2019;12:267-269


How to cite this URL:
Gupta A, Bajaj R, Jindal UN. A rare case of swyer syndrome in two sisters with successful pregnancy outcome in both. J Hum Reprod Sci [serial online] 2019 [cited 2021 Oct 20 ];12:267-269
Available from: https://www.jhrsonline.org/article.asp?issn=0974-1208;year=2019;volume=12;issue=3;spage=267;epage=269;aulast=Gupta;type=0