Journal of Human Reproductive Sciences

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 8  |  Issue : 3  |  Page : 142--145

Clomiphene based ovarian stimulation in a commercial donor program


Shruti Gupta, Ruma Satwik, Abha Majumdar, Shweta Mittal, Neeti Tiwari 
 Centre for IVF and Reproductive Medicine, Sir Ganga Ram Hospital, New Delhi, India

Correspondence Address:
Shruti Gupta
D22, GK2 Enclave, New Delhi - 110 048
India

OBJECTIVE: This study was conducted to compare an extended clomiphene-based ovarian stimulation regimen with the conventional antagonist protocol in donor-recipient cycles. MATERIALS AND METHODS: A total of 170 (N) donors were stimulated between January 2013 and December 2013. Conventional antagonist protocol (group I) was employed in (n1 = 31) cycles, and clomiphene was used in (n2 = 139) donor cycles (group II). 50 mg clomiphene was given simultaneously with gonadotropins from day 2 of the cycle until the day of trigger. The analysis was performed retrospectively for oocytes retrieved, fertilization rates, cycle cancelation, blastocyst formation, and pregnancy rates. The dosages, cost, and terminal E2 (estradiol) were also compared between the two groups. RESULTS: The donor age groups were comparable in both the groups. There were no unsuccessful egg retrievals with clomiphene. The pregnancy rate (positive beta human chorionic gonadotropin) was significantly higher in the clomiphene group (odds ratio: 2.453; P = 0.02). Similarly, fertilization rate was significantly higher in the clomiphene group (59.5/50.5, P = 0.04). Eggs retrieved were similar in both groups, but the terminal E2 was significantly higher in the clomiphene group (P = 0.001). Average gonadotropin used was also significantly lower in clomiphene group (P < 0.001). CONCLUSION: Clomiphene can effectively prevent luteinizing hormone surge and limit the dose of gonadotropins thus bringing down the costs and its negative impact on the endometrium and oocyte quality.


How to cite this article:
Gupta S, Satwik R, Majumdar A, Mittal S, Tiwari N. Clomiphene based ovarian stimulation in a commercial donor program.J Hum Reprod Sci 2015;8:142-145


How to cite this URL:
Gupta S, Satwik R, Majumdar A, Mittal S, Tiwari N. Clomiphene based ovarian stimulation in a commercial donor program. J Hum Reprod Sci [serial online] 2015 [cited 2021 Jul 23 ];8:142-145
Available from: https://www.jhrsonline.org/article.asp?issn=0974-1208;year=2015;volume=8;issue=3;spage=142;epage=145;aulast=Gupta;type=0