Journal of Human Reproductive Sciences

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 8  |  Issue : 2  |  Page : 86--92

Impact of different controlled ovarian stimulation protocols on the physical and psychological burdens in women undergoing in vitro fertilization/intra cytoplasmic sperm injection


Deenadayal Mamata1, Subrat K Ray2, Kumar Pratap3, Parikh Firuza4, Ashish Ramesh Birla2, Banker Manish5 
1 Infertility Institute and Research Center, Hyderabad, Telangana, India
2 Associate Director Medical Affairs, Jaslok Hospital, Mumbai, Maharashtra, India
3 Department of Obstetrics and Gynaecology, Kasturba Medical College, Manipal, Karnataka, India
4 Director of Assisted Reproduction and Genetics, Jaslok Hospital, Mumbai, Maharashtra, India
5 Executive Director Nova IVI Fertility Specialty, Ahmedabad, Gujarat, India

Correspondence Address:
Ashish Ramesh Birla
Organon India Pvt. Ltd., 8th Floor, Platina Bldng., Plot C-59, G.Block, Bandra Kurla Complex, Bandra East, Mumbai - 400 098, Maharashtra
India

Context: Infertility treatment involves a considerable amount of physical and psychological burden which may impact the outcome. Aim: The objective was to understand the amount of physical and psychological burden in women undergoing their first in vitro fertilization (IVF)/intra cytoplasmic sperm injection (ICSI) cycles. Setting and Design: Multi-center, prospective, parallel, observational study. Materials and Methods: The study was conducted across 12 IVF centers in India. A total of 692 women undergoing controlled ovarian stimulation as a part of the first cycle IVF/ICSI completed the trial. Women were recruited in 2 groups based on type of treatment (Group A - gonadotropin-releasing hormone [GnRH] antagonist; Group B - GnRH agonist) and were asked to fill questionnaires during the 2 treatment visits. Results: The mean changes between Visit 1 (baseline) and Visit 2 in anxiety and depression (Hospital Anxiety and Depression Scale) scores in Group A for anxiety and depression were −0.5 (3.67), −0.1 (3.57) respectively and for Group B were −0.4 (3.68), 0.1 (3.67) respectively, which was not statistically significant. In Group A, the mean (±standard deviation [SD]) Hopkins Symptom Check List (HSCL) score was 17.9 (±5.17) in visit 1 and 19.1 (±5.45) Visit 2. The change between visits was 1.1 (P < 0.0001) with higher score reflecting higher somatic distress symptoms. In Group B, the mean (±SD) HSCL score was 18.2 (±5.19) in Visit 1 and 18.8 (±5.23) in visit 2. The change between visits was 0.6 (P < 0.0014). The difference of the mean change in physical burden between Group A and Group B was not statistically significant. Conclusion: A significant impact in both treatment protocols with respect to the physical burden was found between Visit 1 and Visit 2 but no difference in physical or psychological burden between the two treatment groups was observed.


How to cite this article:
Mamata D, Ray SK, Pratap K, Firuza P, Birla AR, Manish B. Impact of different controlled ovarian stimulation protocols on the physical and psychological burdens in women undergoing in vitro fertilization/intra cytoplasmic sperm injection.J Hum Reprod Sci 2015;8:86-92


How to cite this URL:
Mamata D, Ray SK, Pratap K, Firuza P, Birla AR, Manish B. Impact of different controlled ovarian stimulation protocols on the physical and psychological burdens in women undergoing in vitro fertilization/intra cytoplasmic sperm injection. J Hum Reprod Sci [serial online] 2015 [cited 2021 Sep 24 ];8:86-92
Available from: https://www.jhrsonline.org/article.asp?issn=0974-1208;year=2015;volume=8;issue=2;spage=86;epage=92;aulast=Mamata;type=0