Year : 2015 | Volume
: 8 | Issue : 2 | Page : 59--60
From the Editor's desk
Editor in Chief, Journal of Human Reproductive Sciences, Dr. Patil's Fertility & Endoscopy Clinic, No. 1, Uma Admiralty, First Floor, Near Jal Bhavan, Bannerghatta Road, Bangalore - 560029, India
Editor in Chief, Journal of Human Reproductive Sciences, Dr. Patil«SQ»s Fertility & Endoscopy Clinic, No. 1, Uma Admiralty, First Floor, Near Jal Bhavan, Bannerghatta Road, Bangalore - 560029
|How to cite this article:|
Patil M. From the Editor's desk.J Hum Reprod Sci 2015;8:59-60
|How to cite this URL:|
Patil M. From the Editor's desk. J Hum Reprod Sci [serial online] 2015 [cited 2020 Nov 24 ];8:59-60
Available from: https://www.jhrsonline.org/text.asp?2015/8/2/59/158582
This issue has two review articles, one on sperm function test and the other on Understanding normal development of adolescent sexuality. Today postponement of family formation increases the risk of more couples seeking medically assisted reproduction (MAR) treatment, but one must remember that even high-quality MAR treatments cannot overcome the impact of increased female and male age on treatment outcome. There has been a severe decline in the sperm parameters, which are caused by environmental factors or changes in our life- style rather than genetic or pathological factors. Healthy lifestyle may probably have an bearings for prevention of infertility and improved results of MAR treatments. Further investigation of specific spermatozoal factors by utilizing the sperm function tests, will contribute to the development of novel and more personalized approaches to treat male factor infertility. End-point of the infertile male evaluation is to find, if possible, a patho-physiologic specific treatment to achieve spontaneous pregnancy and reduce the need for assisted reproductive technology (ART), downgrade the level of ART needed and increase the pregnancy rates when ART is unavoidable.
Adolescent sexuality is sexual feelings, behavior and development in adolescents. The sexual behavior of adolescents is, in most cases, influenced by their cultural norms and mores, their sexual orientation, and the issues of social control such as age of consent laws. Adolescence can be tough enough to get through without questions of sex, sexuality, and sexual identity, which require programs to educate the adolescent population accurately. The author of the second review article has very dealt on this developmental issue and how the medical fraternity can help this young population.
Though Letrazole is banned in India to be used as an ovulation induction agent, we have a article from Sri Lanka, which discusses the use of Letrazole in clomiphene resistant case. They found that Letrazole in the dose of 2.5 mg may also fail in inducing ovulation and the features associated with resistance show some overlap with those associated with clomiphene resistance. Today the ESHRE/ASRM have proposed Letrazole as the third line of treatment for ovulation induction in women with polycystic ovarian syndrome. The safety of letrozole in pregnancy outcome, studies have been demonstrated by examination of spontaneous pregnancy loss, multiple pregnancy rates, and congenital anomalies compared with a control group of infertility patients treated with CC. Aromatase inhibitors are acceptable alternatives to CC as first line oral agents for ovulation induction or controlled ovarian stimulation due to its simplicity of use and lower antiestrogenic effects on the oocyte, cervix and endometrium.
The second original article is on the effect of progesterone elevation (PE) and progesterone/ estradiol ratio elevation on the day of hCG. Today there is a lot of evidence on decreased probability of pregnancy achievement in fresh IVF cycles in women undergoing ovarian stimulation using GnRH analogues and gonadotropins (GT) who have an elevated progesterone and progesterone/estradiol ratio. Therefore measuring progesterone and estradiol on the day hCG is essential.
Patients are too stressed undergoing IVF treatment. The stress experienced will be personal and unique to each patient based upon his or her own personality and life experiences. Dealing with the treatment protocol, injections, ultrasonography, the apprehension of failure and financial burden are major factors that need to be counseled. Dr. Mamata Deenadayal in her original study has evaluated the psychological and physical burden in the Indian scenario.
Ovarian hyperstimulation syndrome (OHSS) is a serious and detrimental complication of ART due to ovarian stimulation and use of HCG for triggering. All women undergoing controlled ovarian stimulation (COS) should be considered potentially at risk of developing OHSS and HCG is primary stimulus for the syndrome and withholding hCG is the main preventive measure. In the past apart from cancellation, none of the approaches were totally efficient, although they decrease the incidence in patients at high risk of OHSS. But today we have a option of GnRH agonist trigger in an GnRH antagonist cycle with cryopreservation of all embryos, to be transferred in subsequent cycles. This is an efficient, safe and simple method of preventing OHSS. We have a original paper from Manipal, India, who have used hematocrit, which is a simple, inexpensive and fairly accurate test for predicting the development of OHSS in ART and deferring embryo transfer in patients with elevated hematocrit to prevent its development.
High pressures during oocyte retrieval may damage the cumulus oocyte complex. One original study published in this issue had used higher aspiration pressure of 140-mmHg in women with low ovarian reserve and were successful in obtaining a better oocyte yield and pregnancy outcome compared to flushing and aspiration. There is one more original article on adipose tissue-derived mesenchymal stem cells repair of germinal cells of seminiferous tubules in busulfan-induced azoospermic rats.
There are two case reports, one on hypoactive sexual desire disorder caused by antiepileptic drugs and the other on presence of balanced chromosomal translocations in females with recurrent spontaneous abortions.