Journal of Human Reproductive Sciences

ORIGINAL ARTICLE
Year
: 2012  |  Volume : 5  |  Issue : 2  |  Page : 200--205

The role of Allium cepa on aluminum-induced reproductive dysfunction in experimental male rat models


Serah F Ige, Roland E Akhigbe 
 Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria

Correspondence Address:
Serah F Ige
Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State
Nigeria

Aim: Reproductive toxicity is a major challenge associated with aluminum (Al) exposure. Studies that associated Al with reproductive dysfunction did not account for the possible influence of Allium cepa extract. This study, therefore, investigates the influence of A. cepa on aluminum-induced reproductive dysfunction. Materials and Methods: Six male rats per group were assigned to one of the following four treatment groups: The control animals were on control diet. A. cepa-treated rats received 1 ml of the extract/100 g body weight (BW), Al-treated rats received 100 mg AlCl 3 /kg BW, and A.cepa+Al received 1 ml of the extract/100 g BW plus 100 mg AlCl 3 /kg BW. Rats were orally administered their respective doses. A. cepa treatment was for 8 weeks, while Al treatment was for the last 3 days of the experimental period. Results: Results obtained showed that Al significantly decreased (P < 0.05) plasma testosterone, follicular stimulating hormone (FSH), luteinizing hormone (LH), sperm count, motility, morphology and viability, superoxide dismutase (SOD) and catalase (CAT) activities, while lipid peroxidation index [malondialdehyde (MDA)] was significantly (P < 0.05) increased. Reproductive hormones (except testosterone), sperm qualities, and enzymatic antioxidants were significantly (P < 0.05) increased in A. cepa-treated rats and A. cepa plus Al-treated rats, while MDA was significantly (P < 0.05) improved. Weights of testes were comparable in all groups. Conclusion: It is thus suggested that Al exerts reproductive dysfunction by oxidative damage. A. cepa antagonizes the toxic effects of AlCl 3 and improves the antioxidant status and sperm quality of male rat. However, testosterone level did not increase with A. cepa treatment.


How to cite this article:
Ige SF, Akhigbe RE. The role of Allium cepa on aluminum-induced reproductive dysfunction in experimental male rat models.J Hum Reprod Sci 2012;5:200-205


How to cite this URL:
Ige SF, Akhigbe RE. The role of Allium cepa on aluminum-induced reproductive dysfunction in experimental male rat models. J Hum Reprod Sci [serial online] 2012 [cited 2020 Oct 20 ];5:200-205
Available from: https://www.jhrsonline.org/article.asp?issn=0974-1208;year=2012;volume=5;issue=2;spage=200;epage=205;aulast=Ige;type=0