Journal of Human Reproductive Science
Home Ahead of Print Current Issue Archives
   Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size    Users online: 858


 
ORIGINAL ARTICLE Table of Contents   
Year : 2021  |  Volume : 14  |  Issue : 2  |  Page : 113-120
Observable protective activities of quercetin on aluminum chloride-induced testicular toxicity in adult male Wistar Rat


1 Department of Anatomy, Ben Carson School of Medicine, Babcock University, Ilishan-Remo, Ogun State; Department of Anatomy, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, Nigeria
2 Department of Anatomy, Ben Carson School of Medicine, Babcock University, Ilishan-Remo, Ogun State, Nigeria
3 Department of Anatomy, Ben Carson School of Medicine, Babcock University, Ilishan-Remo, Ogun State, Nigeria; Department of Anatomy, Division of Basic Medical Sciences, University of Global Health Equity, Kigali, Rwanda
4 Department of Anatomy, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, Nigeria

Correspondence Address:
Dr. John Afees Olanrewaju
Department of Anatomy, Ben Carson School of Medicine, Babcock University, Ilishan.Remo, Ogun State
Nigeria
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jhrs.jhrs_190_20

Rights and Permissions

Background: Aluminum chloride (AlCl3 ) present in many manufactured consumable is considered as a toxic element. Aim: Our study evaluates the toxic effects induced by AlCl3 on the testes as well as the therapeutic tendency of Quercetin (QUE) agent as an antioxidant. Setting and Design: In the department of Anatomy of Medical School. Methods and Materials: Thirty-two male Wistar rats weighing approximately 170 ± 10 g were assigned into four groups with eight each, fed with rat chow and water ad-libitum. Group A served as control and was given distilled water throughout; Group B was given only QUE (200 mg/kg body weight) for 21 days; Group C was given only AlCl3 (300 mg/kg body weight) for 14 days; and Group D was given AlCl3 (300 mg/kg body weight) for 14 days followed with QUE (200 mg/kg body weight) for 21 days. Substance administrations were done orally. Statistical analysis: One-way analysis of variance was used to analyze the data, in GraphPad Prism 6.0 being the statistical software. Results: AlCl3 significantly reduced the relative organ (testes) weight, correlating the decrease in sperm count, sperm motility and sperm viability. Furthermore, there was a decrease in luteinizing hormone with an increase in follicle-stimulating hormone which accounted for a significant reduction in testosterone level that plays a great role in spermatogenesis, following AlCl3 treatment. The cytoarchitecture of the testes showed degenerative changes in the seminiferous tubules and leydin cells, nitric oxide synthases immunoreactivity was intense in the seminiferous epithelium of rat in Group C. Conclusion: These suggest that QUE antioxidant property could reverse the decrease in sperm status, hormonal effects, and functional deficit induced by aluminum chloride on the testes of Wistar rats.


[FULL TEXT] [PDF]*
Print this article  Email this article
    

  Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
   Citation Manager
  Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed232    
    Printed0    
    Emailed0    
    PDF Downloaded45    
    Comments [Add]    

Recommend this journal