Journal of Human Reproductive Science
Home Ahead of Print Current Issue Archives
   Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size    Users online: 236


 
ORIGINAL ARTICLE Table of Contents   
Year : 2021  |  Volume : 14  |  Issue : 1  |  Page : 42-48
Association of follicular fluid advanced glycation end-products with oocyte response and clinical pregnancy in assisted reproduction cycles


1 Department of Reproductive Medicine and Surgery, IQRAA International Hospital and Research Centre, Kozhikode, Kerala, India
2 Department of Reproductive Medicine and Surgery, Amrita Institute of Medical Sciences, Kochi, Kerala, India
3 Department of Biochemistry, Amrita Institute of Medical Sciences, Kochi, Kerala, India
4 Department of Reproductive Medicine, Gunasheela Surgical and Maternity Hospital, Bangalore, Karnataka, India

Correspondence Address:
Dr. Fessy Louis Thalakkattoor
Department of Reproductive Medicine and Surgery, Amrita Fertility Centre, Unit of Amritha Institute of Medical Sciences,Opposite Shipyard, Atlantis Junction, Thevara, Kochi - 682 015, Kerala
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jhrs.JHRS_130_20

Rights and Permissions

Context: Advanced glycation end-products (AGEs) are toxic metabolic end-products of lipids, nucleic acids, and proteins. Their accumulation in the ovaries can alter the follicular microenvironment and affect stimulation response. Aims: We aimed to study the association of AGEs in follicular fluid (FF AGE) with oocyte response and clinical pregnancy in ART-Assisted Reproductive Technology cycles. Settings and Design: This prospective study involved 84 individuals undergoing ART. Methods and Material: FF was collected during oocyte retrieval, and the level of AGEs was measured by enzyme-linked immunosorbent assay. Oocyte response was grouped as below target (<7 MII oocytes) or above target response (≥7 MII). Statistical Analysis Used: The association of FF AGE with the oocyte response and clinical pregnancy rate was analyzed by Mann–Whitney U-test. The strength of association of FF AGE with the outcome variables was analyzed with receiver operating characteristic (ROC) curve. Results: The median FF AGE was 17.6 (8.5) μg/ml. It was significantly higher in the below target than the normal ovarian response group (18.5 [17.8] vs. 16.3 [7.8] μg/ml, P = 0.046). Similarly, it was significantly higher in those who did not conceive (19.9 [7.3] vs. 13.5 [5.9] μg/ml, P < 0.001). The cutoff of FF AGE obtained by ROC curve analysis was 16.5 μg/ml above which there were significantly lower oocyte response and clinical pregnancy. Conclusions: Elevated FF AGE can be a significant negative predictor of clinical pregnancy and ovarian response to stimulation in ART cycles. The FF AGE level above the cutoff value of 16.5 μg/ml was associated with significantly lower oocyte response and clinical pregnancy.


[FULL TEXT] [PDF]*
Print this article  Email this article
    

  Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
   Citation Manager
  Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed324    
    Printed4    
    Emailed0    
    PDF Downloaded60    
    Comments [Add]    

Recommend this journal