Journal of Human Reproductive Science
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Year : 2016  |  Volume : 9  |  Issue : 1  |  Page : 1-2

From the Editor's desk

Editor-in-Chief, Journal of Human Reproductive Sciences

Date of Submission11-Mar-2016
Date of Decision11-Mar-2016
Date of Acceptance11-Mar-2016
Date of Web Publication14-Mar-2016

Correspondence Address:
Madhuri Patil
Editor-in-Chief, Journal of Human Reproductive Sciences

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-1208.178639

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How to cite this article:
Patil M. From the Editor's desk. J Hum Reprod Sci 2016;9:1-2

How to cite this URL:
Patil M. From the Editor's desk. J Hum Reprod Sci [serial online] 2016 [cited 2022 Nov 27];9:1-2. Available from:

Endometrium equally important as the quality of blastocyst for implantation. In in-vitro fertilization (IVF) controlled ovarian stimulation (COS) has detrimental effect on the endometrium and therefore can affect the implantation and pregnancy rates in IVF. Dose and duration of estrogen (E2) exposure influences the endometrial thickness (ET) and thin endometrium reflects insufficient E2 priming. We also know that ET along with other ultrasound (USG) markers like endometrial pattern, echogenecity, Doppler blood flow studies, myometrial contractions on the day of human chorionic gonadotropin (HCG) are more predictive of pregnancy. The review article in this issue discusses the problems of thin endometrium and how we could overcome this problem. The negative effect of COS can be overcome by performing frozen embryo transfers (FET) in a hormone replacement cycle (HRT).

Laparoscopy may be required in number of sub-fertile patients for both diagnosis and treatment. If not performed properly it can result in both anaesthetic and surgical complications. Thus safety is of prime concern when performing laparoscopy. An original article discusses a new safe portal for laparoscopic entry in women with previous surgeries. This study concluded that this new port entry can significantly reduce inadvertent injury to intra-abdominal structures and improve patient safety.

Autoimmune thyroid disease is a common disorder especially in women and it has been observed that both genetic and environmental factors are involved in its pathogenesis. Elevated anti-thyroid peroxidase antibodies are associated with the treatment response in polycystic ovary syndrome (PCOS) women. It was also found to be associated with poor pregnancy and delivery outcomes. Sheetal Arora from Delhi has investigated the possible correlation between autoimmune markers of autoimmune thyroiditis (AIT) and PCOS. In their study they found a higher prevalence of AIT in PCOS subjects, which suggests a possible role of autoimmune phenomenon in the etiopathogenesis of PCOS.

Endometrial receptivity is acquisition of adhesion ligands and loss of inhibitory components that may act as a barrier to an attaching embryo. High estradiol levels on the day of hCG in a COS cycle decrease the endometrial receptivity as they act via ER to inhibit integrin expression, thus reduce the implantation and pregnancy rates. This was contradicted by the article of Siddhartha et al who found better fertilization and pregnancy rates in women who had high estradiol levels.

When the infertile couples are unable to fulfill their social duty of being family, being mother or father, their adaptation in the society is impaired. This then results in stress. However, women and men may response differently to infertility and its treatment process. Infertility affects the couple's social life, emotional status, marital relationship, sexual life, plans for future, self- esteem and body image negatively and lead infertile couples to experience life crisis. There was a study conducted at Manipal, which through a “semi-strucered questionnaire ” assessed the 300 infertile couples visiting a tertiary center for infertility treatment. They found that there exists a baffling, dynamic, and complex interplay between infertility stress, its predictors, and mediators. They recommend psychological/ psychiatric consultations as a routine in this group of patients. The routine psychological counseling will help in reducing stress and having an optimal treatment outcome.

Infertility is frequently attributed to defects of sperm motility and number in 15 % of couples. Mitochondrion and mitochondrial DNA (mtDNA) play an important role in variety of physiological process especially motility in the sperm. Mitochondrai is major source of oxidative energy through production of adenosine triphosphate (ATP) necessary for growth, development and differentiation. As mitochondria supply energy by OXPHOS, any mutation in mtDNA disrupts ATP production and thus result in an impaired spermatogenesis and impaired flagellar movement. Prafulla Ambulkar, et al looked at abnormal spermatozoa and mtDNA deletions. They found that abnormal spermatozoa had lost genes (4977-bp) for the oxidative phosphorylation and this resulted in asthenozoospermia and oligo-astheno-teratozoospermia (OAT).

We know that Lactobacillus acidophilus is a gram positive bacteria and some strains have a probiotic characteristic. It occurs naturally in the human and animal gastrointestinal tract and mouth. There is an original paper which has Compared protective properties of Lactobacillus acidophilus in reducing oxidative stress from reproductive organs developed during collagen-induced arthritis in animal model. This study concluded that lactobacillus acidophilus decreased arthritis score and was able to maintain normal histology of reproductive organs. L. acidophilus also maintained oxidative stress parameters from ovaries and testis. There is another original paper on male infertility, which looked at anti-sperm protein targets in azoospermia men. These authors concluded that in obstructive azoospermic patients might produce antibody against two sperm proteins, Tektin-2 and triose phosphate isomerase.

There are two interesting case reports published, one on successful pregnancy following single blastocyst transfer in a renal transplant recipient and the other on rare combination of mullerian anomalies and its management with conservative and effective approach.


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