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| Year : 2015 | Volume
: 8
| Issue : 4 | Page : 191-196 |
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Trends of male factor infertility, an important cause of infertility: A review of literature
Naina Kumar1, Amit Kant Singh2
1 Department of Obstetrics and Gynecology, Mahatma Gandhi Institute of Medical Sciences, Wardha, Maharashtra, India
2 Department of Physiology, Rural Institute of Medical Sciences, Safai, Uttar Pradesh, India
| Date of Submission | 09-May-2015 |
| Date of Decision | 10-Jul-2015 |
| Date of Acceptance | 13-Aug-2015 |
| Date of Web Publication | 25-Nov-2015 |
Correspondence Address:
Naina Kumar
Department of Obstetrics and Gynecology, Mahatma Gandhi Institute of Medical Sciences, Sewagram, Wardha - 442 102, Maharashtra
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0974-1208.170370
 Abstract | | |
Infertility and problems of impaired fecundity have been a concern through ages and is also a significant clinical problem today, which affects 8-12% of couples worldwide. Of all infertility cases, approximately 40-50% is due to "male factor" infertility and as many as 2% of all men will exhibit suboptimal sperm parameters. It may be one or a combination of low sperm concentration, poor sperm motility, or abnormal morphology. The rates of infertility in less industrialized nations are markedly higher and infectious diseases are responsible for a greater proportion of infertility. The present literature will help in knowing the trends of male factor infertility in developing nations like India and to find out in future, various factors that may be responsible for male infertility.
Keywords: Infertility, semen, sperm
How to cite this article:
Kumar N, Singh AK. Trends of male factor infertility, an important cause of infertility: A review of literature. J Hum Reprod Sci 2015;8:191-6 |
| Introduction | |  |
Infertility is a condition with psychological, economic, medical implications resulting in trauma, stress, particularly in a social set-up like ours, with a strong emphasis on child-bearing. According to the International Committee for Monitoring Assisted Reproductive Technology, World Health Organization (WHO), infertility is a disease of reproductive system defined by failure to achieve the clinical pregnancy after 12 months or more of regular unprotected sexual intercourse. [1] It can also be defined as failure of couple to conceive after 12 months of regular intercourse without the use of contraception in women <35 years; and after 6 months of regular intercourse without the use of contraception in women ≥35 years. [2]
| Global incidence of infertility | | |
There are no reliable figures for global prevalence of infertility, [3] but estimates suggest that nearly 72.4 million couples globally experience fertility problems. [4] As per the WHO estimates 60-80 million couples worldwide currently suffer from infertility. [5] It varies across regions of the world and is estimated to affect 8-12% of couples worldwide. [6],[7] It tends to be the highest in countries with high fertility rates; an occurrence termed "barrenness amid plenty." [8] In recent decades, infertility has impacted an increasing number of couples. Approximately, 10% of couples in the United States are defined as infertile based on the inability to conceive after 12 months of unprotected intercourse. [9],[10] According to National Center for Health Statistics, the absolute numbers of impaired fecundity increased by about 2.7 million women, from 4.56 million in 1982 to 7.26 million in 2002, then fell slightly to 6.71 million in 2006-2010. [11] Moreover, the fertility rate in men younger than age 30 years has also decreased worldwide by 15%. [12]
| Infertility in india | | |
As per the WHO, the overall prevalence of primary infertility ranges between 3.9% and 16.8%. [5] Also, the estimates of infertility vary widely among Indian states from 3.7% in Uttar Pradesh, Himachal Pradesh, and Maharashtra, [13] to 5% in Andhra Pradesh, [14] and 15% in Kashmir. [15] Moreover, the prevalence of primary infertility has also been shown to vary across the tribes and castes within the same region in India. [13],[16]
It was reported that 40% of infertility cases were related to men, 40% of women and 20% of both sexes. [17] According to a multicentric study conducted by WHO from 1982 to 1985, 20% of cases were attributed to male factors, 38% to female factors, 27% had causal factors identified in both partners, and 15% could not be satisfactorily attributed to either partner. [18] In Indian couples seeking treatment, the male factor is the cause in approximately 23%. [15] A recent report on the status of infertility in India, states that nearly 50% of infertility is related to the reproductive anomalies or disorders in the male. [19] In addition, over 25% of infertility cases, no detectable cause can be traced after routine tests, which leaves the case as unexplained infertility. [19]
| Male Infertility: An Important Factor | | |
Male infertility refers to a male's inability to result pregnancy in a fertile female. "Male factor" infertility is seen as an alteration in sperm concentration and/or motility and/or morphology in at least one sample of two sperm analyzes, collected 1 and 4 weeks apart. [20] In humans, it accounts for 40-50% of infertility [21],[22],[23] and affects approximately 7% of all men. [24] Male infertility is commonly due to deficiencies in the semen, and semen quality is used as a surrogate measure of male fecundity. [25]
Males with sperm parameters below the WHO normal values are considered to have male factor infertility. [26] The most significant of these are low sperm concentration (oligospermia), poor sperm motility (asthenospermia), and abnormal sperm morphology (teratospermia). Other factors less well associated with infertility include semen volume and other seminal markers of epididymal, prostatic, and seminal vesicle function. [27] As high as 90% of male infertility problems are related to count and there is a positive association between the abnormal semen parameters and sperm count. [28] The problem with sperm count, motility, and morphology stems from disarray in control mechanism, including pre-testicular, testicular, and post-testicular factors. [29]
Hence, semen analysis remains the single most useful and fundamental investigation with a sensitivity of 89.6%, that it is able to detect 9 out of 10 men with a genuine problem of male infertility. [30] It is a simple test that assesses the formation and maturity of sperm as well as how the sperm interacts in the seminal fluid. It also provides insight not only on sperm production (count), but the sperm quality (motility, morphology) as well. [31]
| Normal seminal parameters | | |
Semen analysis is an imperfect tool but remains the cornerstone to investigate male infertility. [32] It must be performed to a consistently high standard in order to evaluate the descriptive parameters of the ejaculate. [20],[33] Although this assay reveals a useful information for the initial evaluation of the infertile male, it is not a test of fertility. [34] It provides no insights into the functional potential of the spermatozoon to undergo subsequent maturation processes required to achieve fertilization. It is important that while the results may correlate with "fertility," the assay is not a direct measure of fertility. [35],[36],[37]
The WHO has revised lower reference limits for semen analyses: The following parameters represent the accepted 5 th percentile (lower reference limits and 95% confidence intervals [CIs] in parentheses), derived from a study of over 1900 men whose partners had a time-to-pregnancy of ≤12 months. [25]
- Volume: 1.5 mL (95% CI: 1.4-1.7)
- Sperm concentration: 15 million spermatozoa/mL (95% CI: 12-16)
- Total sperm number: 39 million spermatozoa per ejaculate (95% CI: 33-46)
- Morphology: 4% normal forms (95% CI: 3-4), using "strict" Tygerberg method [33]
- Vitality: 58% live (95% CI: 55-63)
- Progressive motility: 32% (95% CI: 31-34)
- Total (progressive + nonprogressive motility): 40% (95% CI: 38-42).
| Abnormalities of sperm count and morphology | | |
Sperm abnormalities are a critical factor in male infertility. These abnormalities include:
Abnormalities related to sperm count
- Azoospermia: Absence of sperm in seminal plasma
- Low sperm count (oligozoospermia: <15 million sperms/mL). [25]
Abnormalities related to sperm motility
The efficient passage of spermatozoa through the cervical mucus depends on rapid progressive motility, [38],[39] that is, spermatozoa with a forward progression of at least 25 μm/s. A normal semen analysis must contain at least 50% grade A and B, progressively motile spermatozoa. Persistent poor motility is a predictor of failure in fertilization. [40]
Abnormal sperm structure and shape (teratozoospermia)
For morphology of sperms, smears can be scored using the WHO classification, or by Kruger's strict criteria classification. [41] Morphology should be used along with other parameters, and not as an isolated parameter when determining clinical implications. [42],[43]
| Male infertility on the rise? | | |
Time and again, various studies have been published supporting a decline in sperm quality or dismissing the same. [44],[45],[46],[47],[48] Analysis of retrospective data indicates that sperm counts may have declined in some parts of the world, but there seems to be geographical variations in the semen quality. [49],[50],[51] The reason for geographic variations in semen characteristics is not clear, but it may be due to environmental, nutritional, socioeconomic, or other unknown causes. [52] The decline in the semen quality coincides with an increasing incidence of abnormalities of the male genital tract including testicular cancer and cryptorchidism in various countries. [53],[54]
| Global trends of male infertility | | |
As early as in the 1980s, many scientists/clinicians reported an emerging concern about deteriorating semen quality. [55],[56],[57] To better elucidate this problem, a study was done in 1992, which included the meta-analysis of, which had 61 articles 14,947 men with no previous history of infertility. This study concluded that the mean sperm count of healthy men declined by 1% per year between 1938 and 1990. [44] Furthermore, they reported a statistically significant 50% reduction in the mean sperm count from 113 Χ 10 6 mL−1 in 1940 to 66 Χ 10 6 mL−1 in 1990 and in the seminal volume from 3.40 to 2.75 mL, using linear regression data weighted by the number of men in each study. [44] In 2000, an updated comprehensive meta-analysis was done, which also confirmed the falling trend in sperm count. [58] Also, an another meta-analysis reported that sperm density has decreased globally by about 50% over the past 50-60 years. [31],[44] A study in Finland found a temporal decrease in semen quality in the general population over a period of 1998 to 2006. [59] Another study between 1996 and 2007 in the Sfax area of Southern Tunisia in a sample of 2940 men in infertile relationships concluded the decline in semen quality over a period of 12 years. [60] A retrospective study of 9168 cases (men ages 20 to 77) obtained from Andrology and Reproduction Laboratory in Cordoba, Argentina for 10 years (1995-2004) showed a significant decrease in seminal volume, sperm count, motility, viability and normal morphology, and a reduction in alpha-glucosidase and fructose levels in relation to age. [61] Furthermore, a study at the Reproduction Biology Laboratory of the University Hospital of Marseille (France) between 1988 and 2007, which included semen analysis of 10,932 male partners of infertile couples concluded that the whole population demonstrated the declining trends in sperm concentration (1.5%/year), total sperm count (1.6%/year), total motility (0.4%/year), rapid motility (5.5%/year), and normal morphology (2.2%/year). Also, in the group of selected samples with total normal sperm count, the same trends of sperm quality deterioration with time were observed. [62]
On contrary to this many studies have demonstrated no change in seminal parameters over the time. For example, a cross-sectional study of 4867 men from the general Danish population between 1996 and 2010 concluded that over 15 years, median sperm concentration increased from 43 to 48 million/ml and the total sperm count from 132 to 151 million. The median percentage of motile spermatozoa and abnormal spermatozoa were 68% and 93% and did not change during the study period. [63] Another similar study conducted between 2000 and 2010 among young Swedish men from the general population concluded that there is no evidence of time-related deterioration of semen parameters. [64]
| Trends of male infertility in india | | |
Although, the baseline semen quality and sperm functional parameters in fertile Indian men have been documented, [65] the data on declining sperm count in Indian males is limited. According to a study conducted in South India over a period of 13 years, it was found that the decline in sperm count was 30.31% whereas, sperm motility and morphology was reduced by 22.92% and 51.25%, respectively. [66] More importantly, the increase in the incidence of sperm morphological abnormalities in addition to the low sperm count observed in this study indicates the qualitative impairment of spermatogenesis and perhaps of the Sertoli cells More Details. [67]
Also, the Doctors from the All India Institute of Medical Sciences reported that over 12-18 million couples in India are diagnosed with infertility every year. [68] They have reported that while the sperm count of a normal Indian adult male used to be 60 million/ml three decades ago, it now stands at around 20 million/ml. [69] It was found that majority of men who were exposed to high temperature at their workplace - welders, dyers, blast furnace workers and those employed in cement and steel factories - were more prone to infertility. This is due to excess environmental heat which increases the temperature of the scrotum, causing a negative effect on sperm production. A 1 elevation in testicular temperature leads to 14% depression of spermatogenesis. [68] Not only has quantity of sperm production declined in males across the world, but there has also been a decrease in motility and morphology of the sperms. There has been a 2% decrease in quality of male sperm annually. [69] About 40% men in the reproductive age group are presently recording a quantitative and qualitative decline in sperm quality. [70] According to a 10-year comparison study on sperm quality and quantity (2000-2001 to 2010-2011), the percentage of semen ejaculation, which is considered less than normal (below 4 ml), increased from 34% to 65% and the most suitable ejaculation volume (more than 4 ml) went down from 15% to 3%. [69] As far as the morphology of sperm was concerned, in 2000-2001, 26% of the sperms showed above 60% normality, whereas in 2000-2011 this was reduced to 7%. [69] However, a similar study in Calcutta, which included semen analysis of 3729 men presenting with infertility problems in two distinct decades, that is, between 1981-1985 and 2000-2006 concluded a significant decline in the sperm motility parameters and seminal volume in the present decade, but no change in overall sperm concentration. A decline was seen in sperm motility with increasing age in both decades. [71]
The exact reason for the decline in semen quality is not clear, but it may be due to environmental, nutritional, socioeconomic or other unknown causes. [43],[44],[50],[72] Aging is an important factor responsible for the decline in semen quality, as first described in 1969 by Sasano and Ichijo, that the sperm concentration decreases as men age. They reported that 90% of seminiferous tubules in men in their 20s and 30s contained spermatids, whereas men in their 40s and 50s had spermatids in 50% of their seminiferous tubules. Only 10% of seminiferous tubules from men aged >80 years contained spermatids. [73] In contrast to concentration, evidence consistently indicates that sperm motility decreases with advancing age. [27] Various studies revealed statistically significant decreases in motility of 0.17-0.6% per year of age [44],[48] resulting in a 3-12% decline in motility over 20 years. Similar to motility, morphology appears to decrease with advancing male age. [27] Studies indicate a decline in normal sperm morphology of 0.2-0.9% per year of age, [27] resulting in a 4-18% decrease in normal morphology over a 20-year period. [45],[74]
Also, in utero exposures to exogenous estrogenic compounds are capable of altering neonatal testicular development and reducing sperm production in adult men. [67],[75] Diethylstilbestrol is thought to be responsible for an increase in abnormalities of the reproductive tract and for a reduction in the output and fertilizing potential of sperm of male offspring. [76]
| Conclusion | | |
Hence, male infertility is an important cause of infertility with a strong impact on the psychology and physiology of couple. It can be due to several reasons. Also, the present literature reveals that its trend is increasing in India. Therefore, it's the need of the hour to look into the factors which are causing such a rise in male infertility and attempts should be made to control such factors in near future.
| Way forward | | |
Male infertility is an alarming global health issue that has not been researched or studied to truly understand its magnitude and prevalence. There is still a great need for further research into underlying etiology and treatment of male infertility. In future, we can work together in this field to achieve certain goals like:
- Attempts should be made to reduce the barriers from stigmas associated with infertility due to religious and cultural beliefs so that patients open up and share their problems
- Create a globally accepted population-based calculation in order to understand the prevalence and magnitude of male infertility
- To create awareness about male infertility in society.
The present study is only a review of various studies conducted all over the world. The exact rates of male infertility from developing countries like ours are difficult to find because of the problem with the definition of male infertility and lack of accurate reporting rather than a true reflection of male infertility. But still in future, we can conduct various research studies to find out the major causes of male infertility and can work in that direction to reduce such factors which can affect the future fertility of males.
Acknowledgement
I acknowledge and thank Dr. Namit Kant Singh for his advice and expertise.
Financial support and sponsorship
Nil.
Conflicts of interest
There are no conflicts of interest.
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Antioxidant-Based Therapies in Male Infertility: Do We Have Sufficient Evidence Supporting Their Effectiveness? |
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Improving Reproductive Performance and Health of Mammals Using Honeybee Products |
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Effect of Copper Sulphate and Cadmium Chloride on Non-Human Primate Sperm Function In Vitro |
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Y-Chromosome Microdeletions: A Review of Prevalence, Screening, and Clinical Considerations |
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Copy Number Variation Analysis in Turkish Patients with Congenital Bilateral Absence of Vas Deferens |
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RELATIONSHIP OF SEMINAL FRUCTOSE AND SERUM PROLACTIN LEVELS IN INFERTILE MEN |
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MiR-181a Promotes Spermatogenesis by Targeting the S6K1 Pathway |
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Ginger (Zingiber officinale Roscoe) Improves Ethanol-Induced Reproductive Dysfunction by Enhancing Steroidogenesis and Inhibiting Oxidative Stress and Inflammation |
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Herbal foodstuffs in Avicenna’s recommended diet to improve sperm quality and increase male fertility; an evidence-based approach |
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Cytomegalovirus infection and male infertility: case report |
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Baseline levels of seminal reactive oxygen species predict improvements in sperm function following antioxidant therapy in men with infertility |
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The Effect of Oral Vitamin E on Semen Parameters and IVF Outcome: A Double-Blinded Randomized Placebo-Controlled Clinical Trial |
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Protective Effect of Nano-Vitamin C on Infertility due to Oxidative Stress Induced by Lead and Arsenic in Male Rats |
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A low protein maternal diet during gestation has negative effects on male fertility markers in rats – A Systematic Review and Meta-analysis |
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The effectiveness of weight-loss lifestyle interventions for improving fertility in women and men with overweight or obesity and infertility: A systematic review update of evidence from randomized controlled trials |
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The impact of the origin of surgical sperm retrieval on placental and embryonic development: The Rotterdam Periconception cohort |
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Aqueous leaf extract of
Moringa oleifera
reduced intracellular ROS production, DNA fragmentation and acrosome reaction in Human spermatozoa in vitro
|
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SERPIN A5 may have a potential as a biomarker in reflecting the improvement of semen quality in infertile men who underwent varicocele repair |
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Assessment of serum vitamin D level and seminal vitamin D receptor gene methylation in a sample of Egyptian men with idiopathic infertility |
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Abnormal Y chromosome detection in infertile males using multiplex ligation-dependent probe amplification |
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The role of infections and leukocytes in male infertility |
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DNA variants are an unlikely explanation for the changing quality of spermatozoa within the same individual |
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The effects of tobacco and cannabis use on semen and endocrine parameters in infertile males |
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Are Infertile Men Less Healthy Than Fertile Men? An Analysis of the National Survey for Family Growth |
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Postnatal cadmium administration affects the presence and distribution of carbohydrates in the sperm membrane during maturation in the epididymis in adult Wistar rats |
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Mutations in DNAH8 contribute to multiple morphological abnormalities of sperm flagella and male infertility |
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Current updates and future perspectives in the evaluation of azoospermia: A systematic review |
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Redox Regulation to Modulate Phosphorylation Events in Human Spermatozoa |
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L-amino acid oxidase 1 in sperm is associated with reproductive performance in male mice and bulls |
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When idiopathic male infertility is rooted in maternal malnutrition during the perinatal period in mice |
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An innovative approach to polycystic ovary syndrome |
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Association between the presence of Mycoplasma spp. and male infertility |
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Effects of quetiapine administration on sperm quality and testicular histology |
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Assessing the clinical value of the Kruger strict morphology criteria over the World Health Organization fourth edition criteria |
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Optimal timing for repeat semen analysis during male infertility evaluation |
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A review of methods for preserving male fertility |
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Metal(loid)s and human semen quality: The LIFE Study |
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Barriers and factors associated with significant delays to initial consultation and treatment for infertile patients and partners of infertile patients |
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Stem cell therapy as a recent advanced approach in male infertility |
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Determining the need for fertility care and the acceptability and feasibility of administering a fertility awareness tool from the user’s perspective in a sample of Sudanese infertility patients |
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Ameliorating potential and fertility enhancing activities of nutritional dietary supplementation of D-Ribose –l-Cysteine in cisplatin induced oligoasthenoteratozoospermia and seminiferous epithelium degeneration in adult male Sprague-Dawley rats |
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Novel association of PhosphoSerine PHosphatase (PSPH) gene mutations with male infertility identified through whole exome sequencing of South Indians |
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Diverse role of endocannabinoid system in mammalian male reproduction |
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Development and validation of a novel mail-in semen analysis system and the correlation between one hour and delayed semen analysis testing |
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TG12-T5-V470 haplotype in the CFTR gene is associated with non-obstructive azoospermia in Iranian infertile men |
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Onset of azoospermia in man treated with ipilimumab/nivolumab for BRAF negative metastatic melanoma |
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Comparison of spermatozoal RNA extraction methods in goats |
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Effect of deep transfer and multi-task learning on sperm abnormality detection |
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The effects of broccoli and caraway extracts on serum oxidative markers, testicular structure and function, and sperm quality before and after sperm cryopreservation |
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Decabromodiphenyl ether (BDE-209) exposure to lactating mice perturbs steroidogenesis and spermatogenesis in adult male offspring |
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Effects of Medicines and Supplements on Spontaneous Pregnancy and Semen Parameters in Male Infertility: A Systematic Review Update and Network Meta-Analysis |
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Effect of Titanium Dioxide and Silver Nanoparticles on Mitochondrial Dynamics in Mouse Testis Tissue |
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Microdissection testicular sperm extraction (micro-TESE) in men with infertility due to nonobstructive azoospermia: summary of current literature |
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Male Factors: the Role of Sperm in Preimplantation Embryo Quality |
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Photobiomodulation Therapy Improves Spermatogenesis in Busulfan-Induced Infertile Mouse |
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Diet Supplemented with Chrysophyllum albidum G. Don (Sapotaceae) Fruit Pulp Improves Reproductive Function in Hypertensive Male Rats |
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