Journal of Human Reproductive Science
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ORIGINAL ARTICLE Table of Contents   
Year : 2015  |  Volume : 8  |  Issue : 3  |  Page : 151-158
Effect of endometrial biopsy on intrauterine insemination outcome in controlled ovarian stimulation cycle


1 Department of Obstetrics and Gynecology, ESI-Post Graduate Institute of Medical Science and Research, Basaidarapur, New Delhi, India
2 Department of Biochemistry, ESI-Post Graduate Institute of Medical Science and Research, Basaidarapur, New Delhi, India
3 Department of Pathology, ESI-Post Graduate Institute of Medical Science and Research, Basaidarapur, New Delhi, India

Correspondence Address:
Leena Wadhwa
Flat No. 225, Sector-9, Pocket-1, DDA/SFS, Dwarka, New Delhi - 110 075
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Source of Support: Nil., Conflict of Interest: There are no conflicts of interest.


DOI: 10.4103/0974-1208.165144

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OBJECTIVE: The objective was to evaluate the effect of endometrial biopsy (EB) on intrauterine insemination (IUI) outcome in controlled ovarian stimulation (COS) cycle. DESIGN: Prospective randomized control study. SETTING: Tertiary care center. MATERIALS AND METHODS: A total of 251 subjects were enrolled in the study. Subjects undergoing COS with IUI were randomly allocated into three groups. Group A: EB was taken between D19 and 24 of the spontaneous menstrual cycles that precedes the fertility treatment and IUI, which was done in next cycle (n = 86). Group B: EB was taken before D6 of the menstrual cycle, and fertility treatment and IUI was done in the same cycle (n = 90). Group C: (control group) no EB in previous 3 cycle (n = 75). MAIN OUTCOME MEASURE: Clinical pregnancy rate (CPR). RESULTS: Clinical pregnancy rate was 19.77%, 31.11%, and 9.3% for Group A, Group B, and Group C, respectively. The results show a highly significant value for the paired t-test of intervention Group B and control Group C of the cases (P = 0.000957). CPR was maximum afterfirst cycle of ovulation induction and IUI following EB scratch in both Groups A and in Group B (P < 0.001). CONCLUSIONS: Endometrial biopsy done in early follicular phase in the same cycle of stimulation with IUI gives better CPR as compared with EB done in the luteal phase of the previous cycle.


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