Journal of Human Reproductive Science
Home Ahead of Print Current Issue Archives
   Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size    Users online: 509

ORIGINAL ARTICLE Table of Contents   
Year : 2015  |  Volume : 8  |  Issue : 1  |  Page : 37-42
Variability between the follicular steroid hormone levels in different follicles of the same patient and between patients

1 Departments of Obstetrics, Gynaecology and Reproduction, La Paz University Hospital, Madrid, Spain
2 Clinical Analyzes, La Paz University Hospital, Madrid, Spain

Correspondence Address:
Nayara López Carpintero
Paseo de la Castellana 261, CP 28046, Madrid
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-1208.153125

Rights and Permissions

Context: There is disagreement as to whether the concentration of a substance in follicular fluid is related to the quality of the follicle as a possible reflection of the oocyte quality or whether this concentration is related to the clinical characteristics of the patient. AIM: To establish the variability of steroid hormone levels in follicular fluids from different follicles of the same patient and between patients. Settings And Design: Prospective cohort study. Materials And Methods: In 31 patients who underwent intracytoplasmic sperm injection it was performed an ultrasound guided aspiration of follicular fluid of the first two mature follicles from each ovary. Chemiluminescent microparticle immunoassays were performed to determine the levels of estradiol, progesterone, testosterone, and dehydroepiandrosterone sulfate (DHEA-S). Statistical Analysis: Unconditional mixed model. Results: Variation in estradiol levels between follicles in the same patient was approximately twice the variation between subjects (P = 0.05). In the case of progesterone, the intra-subject variation was similar to the inter-subject variation (P = 0.006). The testosterone levels had a slightly smaller intra-subject variation than inter-subject variation (P = 0.002), and the intra-subject variation in DHEA-S levels was approximately one-fifth of the inter-subject variation (P = 0.0003). Conclusions: The variations in the levels of follicular progesterone and testosterone were similar between patients and between a given patient's follicles; however, the estradiol levels variability was higher among different follicles. The amount of follicular estradiol may be considered a selection tool between the follicles of a given patient.

Print this article  Email this article

  Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
   Citation Manager
  Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded73    
    Comments [Add]    

Recommend this journal