Journal of Human Reproductive Science
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Year : 2014  |  Volume : 7  |  Issue : 3  |  Page : 227

Antibiotics supplemented culture media

1 Medical Center, Shantou, China
2 Hainan Medical University, Haikou, China

Date of Web Publication11-Oct-2014

Correspondence Address:
Sim Sai Tin
Medical Center, Shantou
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-1208.142508

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How to cite this article:
Tin SS, Wiwanitkit V. Antibiotics supplemented culture media. J Hum Reprod Sci 2014;7:227

How to cite this URL:
Tin SS, Wiwanitkit V. Antibiotics supplemented culture media. J Hum Reprod Sci [serial online] 2014 [cited 2023 Mar 27];7:227. Available from:


We would like to discuss on the previous report on "antibiotics supplemented culture media. [1] (Dissanayake et al., "Antibiotics supplemented culture media can eliminate nonspecific bacteria from human semen during sperm preparation for intrauterine insemination. J Hum Reprod Sci 2014;7:58-62.)" Dissanayake et al. noted that "penicillin streptomycin combination could eliminate nonspecific bacteria from semen samples during sperm processing in this population [1]" and also noted "the types of antibiotics and dosage used did not seem to have any harmful effects on human sperm. [1]" In fact, the antibiotic is widely used in sperm preparation. However, the effect of sperm can be varied due to the method of specimen preparation. [2] This should be further assessed adding to the present protocol by Dissanayake et al. [1] For the effect of antibiotic of sperm, although many reports including to the present report show no toxicity of penicillin and streptomycin on sperm, it is well-accepted that penicillin can result in the problem in male fertility. [3] In addition, it is evidenced that streptomycin can result in abnormal sperm head morphology. [4] Therefore, long-term assessment of antibiotic effect is required.

   References Top

Dissanayake DM, Amaranath KA, Perera RR, Wijesinghe PS. Antibiotics supplemented culture media can eliminate non-specific bacteria from human semen during sperm preparation for intra uterine insemination. J Hum Reprod Sci 2014;7:58-62.  Back to cited text no. 1
[PUBMED]  Medknow Journal  
Boomsma CM, Heineman MJ, Cohlen BJ, Farquhar C. Semen preparation techniques for intrauterine insemination. Cochrane Database Syst Rev 2007:CD004507.  Back to cited text no. 2
Schlegel PN, Chang TS, Marshall FF. Antibiotics: Potential hazards to male fertility. Fertil Steril 1991;55:235-42.  Back to cited text no. 3
Alp H, Cirit U, Tas M, Rifaioglu MM, Hatipoglu NK, Aytekin I, et al. Effects of sildenafil citrate, isoniazid, and streptomycin on testicular tissue and epididymal semen quality in rats. Urology 2012;80:953.e9-14.  Back to cited text no. 4


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