Journal of Human Reproductive Science
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ORIGINAL ARTICLE Table of Contents   
Year : 2014  |  Volume : 7  |  Issue : 2  |  Page : 99-106
Cypermethrin-induced reproductive toxicity in the rat is prevented by resveratrol

1 Department of Zoology, Bundelkhand University, Jhansi, Uttar Pradesh, India
2 Department of Biomedical Sciences, Bundelkhand University, Jhansi, Uttar Pradesh, India

Correspondence Address:
Rambir Singh
Department of Biomedical Sciences, Bundelkhand University, Jhansi, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-1208.138867

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Aims : The current study was to assess the protective role of resveratrol in cypermethrin-induced reproductive toxicity in male Wistar rats. Materials and Methods : Rats were exposed to cypermethrin (3.83 mg/kg bw) for 14 days. Pre- and post-treatment of resveratrol (20 mg/kg bw for 14 days) was given to cypermethrin exposed rats. At the end of the experiment, rats were sacrificed, testis and epididymis were removed, sperm characteristics, sex hormones, and various biochemical parameters were studied. Results : Cypermethrin exposure resulted in a significant decrease in weight of testis and epididymis, testicular sperm head counts, sperm motility and live sperm counts and increase in sperm abnormalities. Serum testosterone (T), follicle stimulating hormone (FSH), luteinizing hormone (LH), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), glutathione S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and total protein (TP) content were decreased and lipid peroxidation (LPO) level was increased on cypermethrin exposure. Pre- and post-treatment of resveratrol increased sperm head counts, sperm motility, live sperm counts, T, FSH, LH, GSH, CAT, SOD, GST, GR, GPx and TP contents and decreased LPO. Treatment with resveratrol alone has improved sperm parameters and testicular antioxidant defence system. Conclusion : The study concluded that resveratrol ameliorated cypermethrin-induced testicular damage by reducing oxidative stress and by enhancing the level of sex hormones.

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