Journal of Human Reproductive Science
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ORIGINAL ARTICLE Table of Contents   
Year : 2014  |  Volume : 7  |  Issue : 2  |  Page : 111-118
Fertility preservation outcomes may differ by cancer diagnosis


1 Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, USA
2 Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago; Fertility Centers of Illinois, Orland Park, Illinois, USA

Correspondence Address:
Mary Ellen Pavone
Northwestern University, Feinberg School of Medicine, 675 N. St. Clair, Suite 14 200, Chicago, IL 60611
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-1208.138869

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Context : Cancer survival has improved significantly and maintaining fertility is both a major concern and an important factor for the quality of life in cancer patients. Aims : To explore differences in oocyte stimulation for fertility preservation (FP) patients based on cancer diagnosis. Settings and Deign : Between 2005 and 2011, 109 patients elected to pursue FP at a single institution. Materials and Method : In vitro fertilization (IVF) outcome variables between four cancer diagnostic groups (breast, gynecologic, lymphoma/leukemia and other) and age-matched male factor or tubal factor infertility IVF control group were compared. Statistical Analysis : ANOVA and Chi-square analyses were employed to compare variables between the groups that were normally distributed. Kruskal-Wallis with subsequent Mann-Whitney U-test were used for data that were not normally distributed. Results : Women with gynecologic malignancies were significantly older than the women in the other three groups, but tended to have a better ovarian response. Women with hematologic malignancies were most likely to have been exposed to chemotherapy and had the longest stimulations with a similar number of oocytes retrieved. The age-matched IVF controls had higher peak estradiol levels, number of oocytes obtained, and fertilization rates when compared to cancer patients with or without a history of prior chemotherapy. Conclusions : Factors including age, type of cancer and chemotherapy exposure, can influence response to ovarian stimulation. Discussing these findings with patients presenting for FP may aid in setting realistic treatment expectations.


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