Journal of Human Reproductive Science
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Year : 2013  |  Volume : 6  |  Issue : 2  |  Page : 87

From the Editor's desk

Editor-in-Chief, Journal of Human Reproductive Sciences, India

Date of Submission13-Aug-2013
Date of Decision12-Aug-2013
Date of Acceptance14-Aug-2013
Date of Web Publication28-Aug-2013

Correspondence Address:
Madhuri Patil
Editor-in-Chief, Journal of Human Reproductive Sciences
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-1208.117162

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How to cite this article:
Patil M. From the Editor's desk. J Hum Reprod Sci 2013;6:87

How to cite this URL:
Patil M. From the Editor's desk. J Hum Reprod Sci [serial online] 2013 [cited 2022 Aug 16];6:87. Available from:

This issue has two controversial review articles, one on pre-implantation and the other on post-implantation therapy for the treatment of reproductive failure and the other on current evidence supporting letrozole for ovulation induction. The first article discusses about embryo secreted pre-implantation factor and how this can be treated with the use of granulocyte stimulating factor, intralipid and immunoglobulins. We also know that the use of letrozole is banned in India for ovulation induction, though it has been used in the western countries. It does have an advantage over clomiphene citrate, but large studies are lacking on the teratogenicity, though smaller studies have not shown any effect. We need large RCTs and a fair trial needs to be given to letrozole as ovulation induction agent. There is a good original article on the role of follicular fluid AMH levels as an indicator of functional viability of oocytes. There is another article, which concludes that follicular fluid insulin like growth factor 1(IGF-1) is a good marker of embryo quality and implantation and thus clinical pregnancy rate.

There is an original article on detrimental effect of unilateral and bilateral cryptorchidism on fertility of mice. Humans with non-obstructive azoospermia, where the sperms may not be retrieved from the testis using the fine needle aspiration technique or testicular biopsy, micro-TESA is a good option to obtain sperms. Use of electronic equipments which are used emits a lot of electromagnetic waves, which can affect the fertility both in the male and female. One of the original articles published in this issue discusses the effect of mobile jammers on the sperm.

Today, the incidence of menstrual abnormalities, especially amenorrhea either primary or secondary is increasing. Karyotype abnormalities account a large percentage of cases and therefore it becomes mandatory to perform a cytogenetic examination. Despite improvement in the ovulation induction drugs and protocols and laboratory conditions the clinical pregnancy rate has not remarkably increased.

Today, a lot of non-invasive technologies like metabolomics and embryoscope are available for selection of the embryo. We have an original article from Boston IVF on non-invasive metabolomics analysis using a commercial NIR instrument for embryo selection. This article concludes that metabolomics analysis does not have a beneficial effect on the pregnancy and live birth rates. Immunotherapy with paternal lymphocytes is being used for treatment of repeated first trimester abortions. Ahad Zare from Iran has studied the importance of trace elements on the function of immune system and its correlation with success of lymphocytic immune therapy. Sperm preparation forms an important part of intrauterine insemination and ART. One of the studies in this issue compared swim-up technique and density gradient in achieving a bacteria free sample and concluded that total clearance was not possible by both methods, but this did not affect the sperm recovery.

We also have two interesting case reports one on spontaneous OHSS and the other on use of MRI in diagnosis of obstructive mullerian anomaly.


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