Journal of Human Reproductive Science
Home Ahead of Print Current Issue Archives
   Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size    Users online: 239


 
ORIGINAL ARTICLE Table of Contents   
Year : 2012  |  Volume : 5  |  Issue : 3  |  Page : 248-251
Progesterone supplementation in women with otherwise unexplained recurrent miscarriages


1 St. Michael's Hospital, University Hospitals Bristol NHS Trust; Bristol Centre for Reproductive Medicine, University of Bristol, United Kingdom
2 Department of Obstetrics and Gynaecology and IVF Sulaiman Al-Habib Group of Hospitals, Qassim, Saudi Arabia
3 St. Michael's Hospital, University Hospitals Bristol NHS Trust; Academic Unit of Obstetrics and Gynaecology, School of Clinical Sciences, University of Bristol, United Kingdom

Correspondence Address:
Munawar Hussain
Subspecialty Training Fellow, Reproductive Medicine and Surgery, St. Michael's Hospital, University Hospitals Bristol NHS Trust, Bristol, BS2 8EG
United Kingdom
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-1208.106335

Rights and Permissions

Context: Recurrent miscarriages, the loss of three or more consecutive intrauterine pregnancies before 20 weeks of gestation with the same partner, affect 1%-1.5% of the pregnant population. The inadequate secretion of progesterone in early pregnancy has been proposed as a cause of recurrent miscarriages. Aims: The aim was to investigate the efficacy of progesterone supplementation in patients with unexplained recurrent miscarriages. Settings And Design: This was a 9-year cohort study of women with otherwise unexplained recurrent miscarriages who attended a recurrent miscarriage clinic in a tertiary care university hospital. Subjects and Methods: Women with at least three unexplained recurrent miscarriages were included in the study. They were divided into three groups according to their initial and 48-h repeat progesterone levels. For women with inadequate endogenous progesterone secretion, natural progesterone vaginal pessaries 400 mg 12-hourly were offered until 12 weeks gestation. Statistical Analysis: Proportions and 95% confidence intervals calculated for categorical variables and the chi-square test were used to show statistical significance. Medians and ranges were calculated for noncontinuous variables. Results: Pregnancy cycles (n = 203) were analyzed to examine the miscarriage rate following progesterone supplementation. Overall live birth and miscarriage rates were 63% and 36%, respectively. When analyzed by the number of previous miscarriages there was a reduction in the miscarriage rate following progesterone supplementation in women with 4 previous miscarriages when compared with historical data. Conclusions: Progesterone supplementation may have beneficial effects in women with otherwise unexplained recurrent miscarriages.


[FULL TEXT] [PDF]*
Print this article  Email this article
    

  Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
   Citation Manager
  Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed4506    
    Printed116    
    Emailed0    
    PDF Downloaded264    
    Comments [Add]    
    Cited by others 1    

Recommend this journal