Journal of Human Reproductive Science
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Year : 2012  |  Volume : 5  |  Issue : 2  |  Page : 226

Kisspeptin: Role in reproduction and implications for infertility management

Department of Obstetrics and Gynecology, Reproductive Medicine Unit, Sri Aurobindo Institute of Medical Sciences, Indore, Madhya Pradesh, India

Date of Web Publication14-Sep-2012

Correspondence Address:
Priya B Chittawar
201, Adarsh, SAIMS Campus, Indore Ujjain State Highway, Indore-423111, Madhya Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-1208.101029

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How to cite this article:
Chittawar PB. Kisspeptin: Role in reproduction and implications for infertility management. J Hum Reprod Sci 2012;5:226

How to cite this URL:
Chittawar PB. Kisspeptin: Role in reproduction and implications for infertility management. J Hum Reprod Sci [serial online] 2012 [cited 2021 May 11];5:226. Available from:


Kisspeptins are a family of peptide hormones, which play a critical role in reproduction. They are found in the gonads, nervous system, anterior pituitary, and the placenta toward term. Kisspeptin receptor is a G-protein-coupled receptor found in the central nervous system, anterior pituitary, and the placenta. [1] The kisspeptin acts through its receptor and brings about a release of predominantly Luteinizing Hormone(LH) from the anterior pituitary. The role of kisspeptin in bringing about the mid-cycle LH surge in response to increasing estradiol is being recognized based on rodent studies. [2] Knockout Mice for kisspeptin receptor fail to mount an LH surge. Differential effect of estrogen on KISS 1 secreting neurons in the hypothalamic arcuate nucleus and in the hypothalamic anteroventral periventricular nuclear is responsible for the variable effect of estrogen on the pituitary secretion of gonadotrophins.

Kisspeptin is also involved in the link between nutritional status and fertility through its interaction with leptin, another peptide that is important in regulation of appetite and body weight. [1]

Kisspeptin may provide unique therapies for infertility. It provokes a rise in LH on subcutaneous infusion in normo-ovulatory women especially in the preovulatory phase. Women with hypothalamic amenorrhea show a rise in gonadotrophin level on biweekly injection of kisspeptin. [3] Gonadotrophins are the mainstay of treatment of subfertility at present. They are expensive and can lead to ovarian hyperstimulation syndrome and multiple gestations. The cost of gonadotrophins is prohibitive. Kisspeptin, because of its role in regulating the hypothalamo-pituitary-gonadal axis and causing gonadotrophin release, can be an important therapeutic option in subfertility. Cases of delayed puberty and hypogonadotropic hypogonadism are conditions where administration of kisspeptin shows promise. In addition, tropic action on LH release can be utilized in triggering ovulation in cases of intra-uterine Insemination and in-vitro fertilization cycles. Further study of interaction of kisspeptin with other ligands like leptin and neurokinin B may reveal newer insights into regulation of reproduction and pave way for better therapeutic options for infertility.

   References Top

1.Hameed S, Jayasena CN, Dhillo WS. Kisspeptin and fertility. J Endocrinol 2011;208:97-105.  Back to cited text no. 1
2.D'Anglemont De Tassigny X, Colledge WH. The role of kisspeptin signaling in reproduction. Physiology (Bethesda) 2010;25:207-17.  Back to cited text no. 2
3.Jayasena CN, Nijher GM, Chaudhri OB, Murphy KG, Ranger A, Lim A, et al. Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis. J Clin Endocrinol Metab 2009;94:4315-23.  Back to cited text no. 3


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