Journal of Human Reproductive Science
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Year : 2012  |  Volume : 5  |  Issue : 2  |  Page : 153

From the Editor's desk

Editor-in-Chief, Journal of Human Reproductive Sciences

Date of Submission05-Sep-2012
Date of Decision05-Sep-2012
Date of Acceptance05-Sep-2012
Date of Web Publication14-Sep-2012

Correspondence Address:
Kamini Rao
Editor-in-Chief, Journal of Human Reproductive Sciences

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-1208.101009

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How to cite this article:
Rao K. From the Editor's desk. J Hum Reprod Sci 2012;5:153

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Rao K. From the Editor's desk. J Hum Reprod Sci [serial online] 2012 [cited 2021 May 11];5:153. Available from:

We start this issue of the journal with an article by Madhuri Patil on the importance of early prediction and management of ectopic pregnancy. The article confirms that in patients who are being treated for infertility, performing measurement of β-human chorionic gonadotrophin (β-hCG) levels and a transvaginal ultrasound 20 days after ovulation will help in diagnosing ectopic pregnancy early, making it possible to treat them medically and thus increasing their chances of conceiving in subsequent cycles either naturally or with treatment.

We follow with an article by Pratap Kumar on the encouraging effects of metformin on several metabolic aspects of polycystic ovarian syndrome (PCOS), such as insulin sensitivity, plasma glucose concentration, and lipid profile. The authors have confirmed that since women with PCOS are more likely than healthy women to suffer from pregnancy-related problems like early pregnancy loss, gestational diabetes mellitus, and hypertensive states in pregnancy, the use of metformin therapy in these patients throughout pregnancy may have beneficial effects on early pregnancy loss and development of gestational diabetes.

Prof. Baidya Nath Chakraborty and his team have published a randomized controlled trial that they undertook which shows that the adjunctive use of letrozole with gonadotrophin, especially in women where male factor infertility is the sole indication, going for IVF-ICSI treatment, may be an effective means of low-cost IVF therapy.

Also published is a study conducted by Mohamed Khrouf et al. to evaluate the rabbit as an experimental model for Asherman's syndrome using the endometrial curettage as trigger mechanism and then evaluate its impact on fertility. They concluded that this model represents a pathogenesis condition in the rabbit similar to intrauterine adhesions observed in the human with negative impact on implantation.

For more than 20 years, gonadotropin-releasing hormone (GnRH) agonists have been the gold standard protocol in controlled ovarian hyperstimulation. The vast majority of in vitro fertilization (IVF) treatment cycles are still performed using the GnRH agonist long protocol. We publish a study on the comparison of GnRH agonist long protocol with the flexible GnRH antagonist protocol in infertile PCOS women undergoing controlled ovarian hyperstimulation in terms of clinical pregnancy rate, with special reference to the incidence of ovarian hyperstimulation syndrome (OHSS) in the Indian population. While there was no great difference in the pregnancy rate, the incidence of OHSS was significantly lower in the antagonist protocol. With the rising trend for softer protocols, the antagonist protocol seems to be a good option.

Poor oocyte quality, as reflected by higher mean reactive oxygen species levels in the follicular fluid of women undergoing IVF, and low number of oocytes with spindle visualization could be the factors impeding pregnancy in women with PCOS as compared to women with tubal block. Shweta Rajani and team from Institute of Reproductive Medicine have tried the use of spindle imaging as a predictor of oocyte quality, finally suggesting a possible role of endometrial receptivity rather than oocyte quality accounting for low pregnancy rates in these women.

Jana Chakraborti et al. have shown that elevated leptin response may exert an adverse impact on pregnancy success during IVF-ET possibly by reducing endometrial receptivity.

As editor-in-chief, it is my intention to provide readers of the Journal of Human Reproductive Sciences a personal selection of relevant and interesting articles appearing in each issue of the journal. I again stress that I consider all papers that reach the publication stage of this journal to be of extremely high quality. The papers selected are those that I have found particularly interesting, and I hope that you will think so too.


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