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   Table of Contents     
REVIEW ARTICLE  
Year : 2012  |  Volume : 5  |  Issue : 1  |  Page : 7-13
 

Sample size estimation and power analysis for clinical research studies


1 Department of Biostatistics, National Institute of Animal Nutrition and Physiology, Bangalore, India
2 Department of Immunology and Reumatology, ChanRe Rheumatology and Immunology Center and Research, Bangalore, India

Date of Submission16-Feb-2012
Date of Decision16-Feb-2012
Date of Acceptance07-Mar-2012
Date of Web Publication2-Jul-2012

Correspondence Address:
K P Suresh
Scientist(ss), National Institute of Animal Nutrition and Physiology Adugodi, Bangalore-560030
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-1208.97779

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   Abstract 

Determining the optimal sample size for a study assures an adequate power to detect statistical significance. Hence, it is a critical step in the design of a planned research protocol. Using too many participants in a study is expensive and exposes more number of subjects to procedure. Similarly, if study is underpowered, it will be statistically inconclusive and may make the whole protocol a failure. This paper covers the essentials in calculating power and sample size for a variety of applied study designs. Sample size computation for single group mean, survey type of studies, 2 group studies based on means and proportions or rates, correlation studies and for case-control for assessing the categorical outcome are presented in detail.


Keywords: Correlation, odds ratio, power, prevalence, survey, proportions, sample size


How to cite this article:
Suresh K P, Chandrashekara S. Sample size estimation and power analysis for clinical research studies. J Hum Reprod Sci 2012;5:7-13

How to cite this URL:
Suresh K P, Chandrashekara S. Sample size estimation and power analysis for clinical research studies. J Hum Reprod Sci [serial online] 2012 [cited 2022 Jun 27];5:7-13. Available from: https://www.jhrsonline.org/text.asp?2012/5/1/7/97779


This has been retracted as the sections in the text have been directly copied from a previously published article, entitled, "Issues in outcomes research: An overview of randomization techniques for clinical trials," in pages 215-221, Issue 2, Vol. 45 of Journal of Athletic Training









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83 Hausa translation, cross-cultural adaptation, and assessment of psychometric properties of the Stroke Self-Efficacy Questionnaire
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85 A non-interventional study of microcirculation dynamics in allogeneic hematopoietic cell transplantation survivors compared to controls: evidence of impaired microvascular response regardless of conventional cardiovascular risk factors
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88 Statistics in clinical trials
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89 Doing it Wrong: A Systematic Review on Electrocortical and Behavioral Correlates of Error Monitoring in Patients with Neurological Disorders
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91 Development of voice onset time in Arabic
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92 The impact of adoption of artificial pollination technology in cocoa production: Evidence from Ghana
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94 Cotransplantation of mesenchymal stromal cells and endothelial cells on calcium carbonate and hydroxylapatite scaffolds in vivo
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96 The signal intensity characteristics of normal bone marrow in diffusion weighted imaging at various menstrual status women
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98 Prevalence of gaming disorder: A meta-analysis
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99 The Relationship Between Mindfulness and Happiness in Student-Athletes: The Role of Self-Compassion—Mediator or Moderator?
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101 Effect of Fasting-Mimicking Diet or Continuous Energy Restriction on Weight Loss, Body Composition, and Appetite-Regulating Hormones Among Metabolically Healthy Women with Obesity: a Randomized Controlled, Parallel Trial
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105 Effectiveness of Pain Control of Local Anaesthetic Wound Infusion Following Elective Midline Laparotomy: A Randomized Trial
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106 Investigation on chronic tinnitus efficacy of combination of non-repetitive preferred music and educational counseling: a preliminary study
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109 Lean management for improving hospital waiting times—Case study of a Vietnamese public/general hospital emergency department
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116 Association between the IL-6, IL-10, and TNFa gene polymorphisms and preterm-birth in Korean women
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129 Changes in primary outcome and sample size measures after initiation of accrual among trials supporting approval of drugs for hematological malignancies by the US food and drug administration
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135 Mainstreaming the private health sector in the response to COVID-19: facility readinessassessment for screening services in Edo State, Nigeria
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139 Using data science for medical decision making case: role of gut microbiome in multiple sclerosis
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140 Does Practicing with a Virtual Reality Driving Simulator Improve Spatial Cognition in Older Adults? A Pilot Study
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141 Untreated dental caries prevalence and impact on the quality of life among 11 to14-year-old Egyptian schoolchildren: a cross-sectional study
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143 Sensory Acceptability of Dual-Fortified Milled Red and Yellow Lentil (Lens culinaris Medik.) Dal in Bangladesh
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150 Secondary hyperparathyroidism in patients with chronic kidney disease: A case control study
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151 Sex determination by radiographic localization of the inferior alveolar canal using cone-beam computed tomography in an Egyptian population
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152 Effects of Motor Mental Imagery Training on Tennis Service Performance during the Ramadan Fasting: A Randomized, Controlled Trial
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156 Will Nigerians Win the War Against Urinary Schistosomiasis? Prevalence, Intensity, Risk Factors and Knowledge Assessment among Some Rural Communities in Southwestern Nigeria
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159 Serum coiled-coil domain containing 25 protein as a potential screening/diagnostic biomarker for cholangiocarcinoma
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160 Use and Effectiveness of Unani Medicines as Adjunct Therapy in the Treatment of Diabetes Mellitus: A Cross-sectional Study
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171 Pre-incarceration police harassment, drug addiction and HIV risk behaviours among prisoners in Kyrgyzstan and Azerbaijan: results from a nationally representative cross-sectional study
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