Journal of Human Reproductive Science
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CASE REPORT Table of Contents   
Year : 2008  |  Volume : 1  |  Issue : 2  |  Page : 86-89
Empty follicle syndrome-Still an enigma

O.B.G-Infertility, Dr. Patil's Fertility and Endoscopy Clinic, No1, Uma Admiralty, 1st Floor, Banerghatta Road, Bangalore-560 029, Karnataka, India

Correspondence Address:
Deepika Krishna
O.B.G-Infertility, Dr. Patils fertility and endoscopy clinic, No.1, Uma Admiralty, 1st Floor, Banerghatta Road, Bangalore-560 029, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-1208.44118

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Empty follicle syndrome (EFS), although rare with an incidence of 0.2-7%, is a frustrating condition where no oocytes are retrieved in in vitro fertilization (IVF), even though ultrasound and estradiol measurements show the presence of many potential follicles. It is a complex phenomenon that cannot be explained by low bioavailability of human chorionic gonadotrophin alone; neither can it be reliably diagnosed by the measurement of serum beta-human chorionic gonadotrophin (bhCG) on the day of oocyte retrieval (OR), except possibly when the bhCG concentration is very low. Here we report a case who underwent intracytoplasmic sperm injection (ICSI) for her partner's severe oligoasthenozoospermia. Controlled ovarian hyperstimulation (COH) was done in her first cycle of ICSI, using a gonadotrophin-releasing hormone (GnRH) agonist long protocol with follicle-stimulating hormone (FSH) and human menopausal gonadotrophin (HMG). However, as we were unable to retrieve any oocytes, her COH protocol was changed in the subsequent cycle with a successful outcome.

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