Journal of Human Reproductive Sciences

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 10  |  Issue : 4  |  Page : 281--287

Does perifollicular vascularity on the day of oocyte retrieval affect pregnancy outcome in an In Vitro fertilization cycle?


Nikita Naredi1, Santosh Kumar Singh2, Rajesh Sharma3 
1 Assisted Reproductive Technology Centre, Command Hospital, Pune, Maharashtra, India
2 Department of Obstetrics and Gynaecology, Command Hospital, Pune, Maharashtra, India
3 IVF Specialist Assisted Reproductive Technology Centre, Pune, Maharashtra, India

Correspondence Address:
Prof. Nikita Naredi
IVF Specialist Assisted Reproductive Technology Centre, Command Hospital, Pune - 411 040, Maharashtra
India

Background: The vascularization status of ovarian follicles affects reproductive competence of oocytes and in turn embryo quality by regulating its oxygen supply. Transvaginal power Doppler ultrasound can noninvasively map this vascularity of the ovarian follicles. Thus, we aimed to study the association of perifollicular vascularity and pregnancy outcome in women while on treatment for an in vitro fertilization cycle. Material and Methods: A prospective study on 200 participants evaluated the vascularity of 1008 follicles on the day of oocyte retrieval to outline a map depicting perfusion of each follicle. The vascularity was graded based on percentage of the perifollicular outline in the map depicting vascularity which was Grade 1 ≤25%, Grade 2 26-50%, Grade 3 51-75%, Grade 4 76-100%. Results: Of 1008 follicles aspirated, only 733 follicles were analyzed as per the exclusion criteria. Grades III and IV follicles were high vascular grade follicle whereas Grades I and II were low perfused follicles. Six hundred and twenty-seven oocytes were retrieved from 733 follicles with majority from Grade III and IV vascularity (75.8%: Grade III and IV vs. 24.2%: Grade I and II). The number of oocytes exhibiting maturity and their fertilization rates were significantly higher in high vascularity follicles. Three hundred and forty-one Grade I embryos formed and 89.1% were from better-perfused follicles versus 10.9% from lower ones. Conclusions: The association between perifollicular perfusion and follicular oxygenation and oocyte maturation does exist which ultimately gets translated to quality of embryos. If other confounding factors such as endometrial receptivity and transfer technique are controlled, it influences the implantation potential too.


How to cite this article:
Naredi N, Singh SK, Sharma R. Does perifollicular vascularity on the day of oocyte retrieval affect pregnancy outcome in an In Vitro fertilization cycle?.J Hum Reprod Sci 2017;10:281-287


How to cite this URL:
Naredi N, Singh SK, Sharma R. Does perifollicular vascularity on the day of oocyte retrieval affect pregnancy outcome in an In Vitro fertilization cycle?. J Hum Reprod Sci [serial online] 2017 [cited 2020 Apr 2 ];10:281-287
Available from: http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2017;volume=10;issue=4;spage=281;epage=287;aulast=Naredi;type=0