Year : 2013 | Volume
: 6 | Issue : 4 | Page : 219-
From the editors desk
Editor, Journal of Human Reproductive Science, Dr.Patil's Fertility & Endoscopy Clinic, No.1, Uma Admiralty, First Floor, Near Jal Bhavan, Bannerghatta Road, Bangalore - 560029, India
Editor, Journal of Human Reproductive Science, Dr.Patil«SQ»s Fertility & Endoscopy Clinic, No.1, Uma Admiralty, First Floor, Near Jal Bhavan, Bannerghatta Road, Bangalore - 560029
|How to cite this article:|
Patil M. From the editors desk.J Hum Reprod Sci 2013;6:219-219
|How to cite this URL:|
Patil M. From the editors desk. J Hum Reprod Sci [serial online] 2013 [cited 2020 Jul 3 ];6:219-219
Available from: http://www.jhrsonline.org/text.asp?2013/6/4/219/126281
In this issue, we have three review articles. Two of them are on ovarian stimulation, and the third review is 3 years analysis of the assisted reproductive technology registry in India.
We know that over the last 35 years, there has been a major progress in improving the stimulation protocols and fertilization procedures, optimizing embryo culture conditions and preventing premature luteinization. However, this has not translated in increasing the live birth rates as only marginal improvement was seen in the implantation rates. Today there is a lot of evidence accumulating on improved live birth rates with the use of mild stimulation protocols apart from reduction in the physical, financial and emotional burden. The other article on ovulation induction discusses on the role of luteinizing hormone (LH) in controlled ovarian stimulation (COS). Most evidence have shown that in most cases follicle stimulating hormone alone is enough for COS, but there exists a small which would benefit from addition of LH and it is important for us to identify this group.
An original article, which compared the pregnancy rates in two groups of women who underwent intrauterine insemination, one when semen preparation was done with non-temperature controlled centrifugation and the other with temperature controlled and the study did not show any statistical difference in the pregnancy rates. There is another article on assessing a successful outcome after in vitro fertilization by estimating beta human chorionic gonadotropin levels 14 days after the embryo transfer and repeating it after 48 h, if positive.
Today with the use of individualized protocols the incidence of ovarian hyper stimulation (OHSS) had reduced considerable, but with many patients having polycystic ovaries, we still see cases of OHSS. We have been using today gonadotrophin-releasing hormone (GnRH) antagonist protocol with GnRH agonist trigger and cabergoline a dopamine agonist from the day of oocyte retrieval to prevent OHSS. This study has used calcium gluconate infusion, instead of cabergoline in patients at risk of developing OHSS and has found it to be as effective. There is another paper on the role of melatonin in women with polycystic ovary syndrome with disturbed hormonal milieu.
Today it has been observed that women are delaying child bearing, resulting in poor ovarian response to COS. It is important to identify this group of women and hence that we can tailor individualized protocols and optimize the outcome. Combination of antimullerian hormone and age has been suggested to be good predictors of response, in women who are poor responders by Jeve in her paper. We have another original paper on choosing the anesthetic agents for oocyte retrieval, especially in those women who have a history of autosomal disease that can impact the systemic management. This study has found a combination of propofol and fentanyl safe.
We also have an animal study in rats, where the effect of low and high salt diet was studied on the sperm parameters. This study can be concluded that low salt diet decreased, whereas high salt diet increased the sperm count in male rats. They also notice an increased epididymal oxidative stress in both groups.
We have two interesting cases, one on diagnosis and management of cervical ectopic pregnancy and other on Turner's syndrome with mullerian agenesis.