Journal of Human Reproductive Sciences

REVIEW ARTICLE
Year
: 2013  |  Volume : 6  |  Issue : 3  |  Page : 176--182

A clinical appraisal of the genetic basis in unexplained male infertility


Sandro C Esteves 
 Male Infertility Sector ANDROFERT, Andrology and Human Reproduction Clinic, Referral Center for Male Reproduction, Campinas, São Paulo, Brazil

Correspondence Address:
Sandro C Esteves
ANDROFERT, Andrology and Human Reproduction Clinic and Referral Center for Male Reproduction, Campinas, São Paulo 13075 460
Brazil

Unexplained male infertility (UMI), the inability to reproduce despite having a normal sexual history, physical exam and semen analysis, can have a genetic origin. Currently, few diagnostic tools are available for detecting such genetic abnormalities. Karyotyping and fluorescence in situ hybridization (FISH) are respectively used for chromosomal alterations in somatic cells and sperm aneuploidy assessment. Gene sequencing and mutational analysis have been introduced for identifying specific mutations and polymorphisms. Other approaches to the molecular evaluation of spermatozoa are under investigation, including array comparative genomic hybridization and whole-genome sequencing and non-coding ribonucleic acid arrays. Although treating cytogenetic abnormalities and genetic aberrations is still out of reach, the integration of these novel techniques may unravel hidden genetic defects in UMI. Finally, a deeper understanding of the sperm epigenome might allow the development of therapies based on epigenome modifications. This review focuses on the genetic basis of UMI and highlights the current and future methods for the evaluation of genetic defects as they relate to UMI. Review of the literature was carried out using ScienceDirect, OVID, PubMed and MedLine search engines.


How to cite this article:
Esteves SC. A clinical appraisal of the genetic basis in unexplained male infertility.J Hum Reprod Sci 2013;6:176-182


How to cite this URL:
Esteves SC. A clinical appraisal of the genetic basis in unexplained male infertility. J Hum Reprod Sci [serial online] 2013 [cited 2020 May 28 ];6:176-182
Available from: http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2013;volume=6;issue=3;spage=176;epage=182;aulast=Esteves;type=0