Journal of Human Reproductive Sciences

ORIGINAL ARTICLE
Year
: 2013  |  Volume : 6  |  Issue : 1  |  Page : 9--14

Prevalence of hepatic steatosis in women with polycystic ovary syndrome


Ritu Karoli1, Jalees Fatima1, Ashok Chandra1, Uma Gupta2, Faraz-ul Islam1, Gagandeep Singh1 
1 Department of Medicine, Era's Lucknow Medical College, Sarfarazganj, Hardoi Road, Lucknow, Uttar Pradesh, India
2 Department of Obstetric and Gynecology, Era's Lucknow Medical College, Sarfarazganj, Hardoi Road, Lucknow, Uttar Pradesh, India

Correspondence Address:
Ritu Karoli
Department of Medicine, Era’s Lucknow Medical College, Sarfarazganj, Hardoi Road, Kundari Rakabganj, Lucknow, Uttar Pradesh
India

Objective: Nonalcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS) both are known to be associated with insulin resistance and metabolic syndrome (MS). The aim of the study was to determine the presence of NAFLD and associated factors of hepatic steatosis in women with PCOS. Materials and Methods: A cross-sectional hospital based study of 54 women with PCOS and 55 healthy controls who were age and weight matched were included. Anthropometric parameters, biochemical and hormonal investigations were done in all the patients. Insulin resistance was calculated by Homeostasis model assessment (HOMA). Abdominal ultrasonography and biochemical tests were used to determine the presence of hepatic steatosis after excluding other causes liver disease. Results : Women with PCOS had a higher prevalence of hepatic steatosis (67% vs 25%, P = 0.001) MS (35% vs. 7%, P < 0.01) and elevated transaminases (31% vs. 7%, P = 0.03) than controls. All patients with PCOS and controls with MS had presence of hepatic steatosis. Age, BMI, waist-hip ratio, HOMA-IR, HDL and PCOS diagnosis were the factors associated with presence of hepatic steatosis. Conclusion : NAFLD is commonly present in women with PCOS in combination with other metabolic derangements. Evaluation for liver disease should be considered at an earlier age in women with PCOS, particularly those who have an evidence of MS.


How to cite this article:
Karoli R, Fatima J, Chandra A, Gupta U, Islam Fu, Singh G. Prevalence of hepatic steatosis in women with polycystic ovary syndrome.J Hum Reprod Sci 2013;6:9-14


How to cite this URL:
Karoli R, Fatima J, Chandra A, Gupta U, Islam Fu, Singh G. Prevalence of hepatic steatosis in women with polycystic ovary syndrome. J Hum Reprod Sci [serial online] 2013 [cited 2020 Aug 9 ];6:9-14
Available from: http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2013;volume=6;issue=1;spage=9;epage=14;aulast=Karoli;type=0