Journal of Human Reproductive Sciences

ORIGINAL ARTICLE
Year
: 2012  |  Volume : 5  |  Issue : 1  |  Page : 20--25

A prospective randomized trial comparing the efficacy of Letrozole and Clomiphene citrate in induction of ovulation in polycystic ovarian syndrome


Kallol Kumar Roy, Jinee Baruah, Shilpa Singla, Jai Bhagwan Sharma, Neeta Singh, Sunesh Kumar Jain, Manu Goyal 
 Department of Obstetrics and Gynecology, All India Institute of Medical Sciences (AIIMS), New Delhi, India

Correspondence Address:
Kallol Kumar Roy
Department of Obstetrics and Gynecology, Room no 3085, 3rd Floor, Teaching Block, AIIMS, New Delhi - 110 029
India

Objectives: To compare the efficacy of letrozole and clomiphene citrate (CC) in patients of anovulatory polycystic ovarian syndrome (PCOS) with infertility. Materials and Methods: This prospective randomized clinical trial included 204 patients of PCOS. 98 patients (294 cycles) received 2.5-5 mg of letrozole; 106 patients (318 cycles) received 50-100 mg of CC (both orally from Days 3-7 of menstrual cycle). The treatment continued for three cycles in both the groups. Main outcome measures: ovulation rate, endometrial thickness, and pregnancy rate. Statistical analysis was done using SPSS 13 software. P value less than 0.05 was considered significant. Results: The mean number of dominant follicles in letrozole groups and CC groups was 1.86±0.26 and 1.92±0.17, respectively (P=0.126). Number of ovulatory cycle in letrozole group was 196 (66.6%) versus 216 (67.9%) in CC group (P=0.712). The mean mid-cycle endometrial thickness was 9.1±0.3 mm in letrozole group and 6.3±1.1 in CC group, which was statistically significant (P=0.014). The mean Estradiol [E2] level in clomiphene citrate group was significantly higher in CC group (364.2±71.4 pg/mL) than letrozole group (248.2± 42.2 pg/mL). 43 patients from the letrozole group (43.8%) and 28 patients from the CC group (26.4%) became pregnant. Conclusion: Letrozole and CC have comparable ovulation rate. The effect of letrozole showed a better endometrial response and pregnancy rate compared with CC.


How to cite this article:
Roy KK, Baruah J, Singla S, Sharma JB, Singh N, Jain SK, Goyal M. A prospective randomized trial comparing the efficacy of Letrozole and Clomiphene citrate in induction of ovulation in polycystic ovarian syndrome.J Hum Reprod Sci 2012;5:20-25


How to cite this URL:
Roy KK, Baruah J, Singla S, Sharma JB, Singh N, Jain SK, Goyal M. A prospective randomized trial comparing the efficacy of Letrozole and Clomiphene citrate in induction of ovulation in polycystic ovarian syndrome. J Hum Reprod Sci [serial online] 2012 [cited 2020 Apr 8 ];5:20-25
Available from: http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2012;volume=5;issue=1;spage=20;epage=25;aulast=Roy;type=0