Journal of Human Reproductive Sciences

ORIGINAL ARTICLE
Year
: 2011  |  Volume : 4  |  Issue : 2  |  Page : 86--90

Investigating the association between polymorphism of follicle-stimulating hormone receptor gene and ovarian response in controlled ovarian hyperstimulation


Mohammad Hasan Sheikhha1, Maryam Eftekhar2, Seyed Mehdi Kalantar1 
1 Department of Genetics, Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2 Departments of Obstetrics and Gynecology, Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Correspondence Address:
Mohammad Hasan Sheikhha
Associated Professor of Medical Genetics, Research and Clinical Canter for Infertility, Booali Avenue, Safayeh, Yazd
Iran

Aim : The aim of the study was to investigate the association between follicle-stimulating hormone receptor (FSHR) gene polymorphism at Position 680 and the outcomes of controlled ovarian hyperstimulation for in vitro fertilization and embryo transfer (IVF-ET) in infertile women. Materials and Methods : One hundred and eight patients under 35 years of age who underwent IVF-ET procedures were included in this study. The hormonal profile and treatment of all patients were analyzed and FSHR polymorphism was examined by polymerase chain reaction-restriction fragment length polymorphism. Women from all groups were classified based on polymorphisms at Position 680, occupied either by asparagines (Asn) or serine (Ser) as Asn/Asn, Asn/Ser, and Ser/Ser genotype. Result : Our study showed that all patients in the Asn/Asn group were normal responders and in the Asn/Ser group 64.8% were normal responders and 21.1% and 14.1% were poor and hyper responders respectively. In the Ser/Ser group we did not have normal responders and 46.7% of these patients were poor responders and 53.3% were hyper responders. Conclusion : FSH receptor polymorphism is correlated with response to ovarian stimulation.


How to cite this article:
Sheikhha MH, Eftekhar M, Kalantar SM. Investigating the association between polymorphism of follicle-stimulating hormone receptor gene and ovarian response in controlled ovarian hyperstimulation.J Hum Reprod Sci 2011;4:86-90


How to cite this URL:
Sheikhha MH, Eftekhar M, Kalantar SM. Investigating the association between polymorphism of follicle-stimulating hormone receptor gene and ovarian response in controlled ovarian hyperstimulation. J Hum Reprod Sci [serial online] 2011 [cited 2020 May 28 ];4:86-90
Available from: http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2011;volume=4;issue=2;spage=86;epage=90;aulast=Sheikhha;type=0