Year : 2011 | Volume
: 4 | Issue : 1 | Page : 1-
From the Editor's Desk
Editor-in-Chief, Journal of Human, Reproductive Sciences, India
Editor-in-Chief, Journal of Human, Reproductive Sciences
|How to cite this article:|
Rao K. From the Editor's Desk.J Hum Reprod Sci 2011;4:1-1
|How to cite this URL:|
Rao K. From the Editor's Desk. J Hum Reprod Sci [serial online] 2011 [cited 2020 Jul 3 ];4:1-1
Available from: http://www.jhrsonline.org/text.asp?2011/4/1/1/82350
The controversy surrounding the role of the luteinizing hormone (LH) in ovarian stimulation and the concept of a 'therapeutic window' of LH has been addressed in our first review article by Pratap Kumar and Sameer Farouk Sait. Levels under which low LH concentrations may be equally or suboptimally needed for oocyte quality and subsequent embryonic development competence have been reviewed, along with the data related to the high levels of LH promoting follicular atresia. However, further studies are required before we can determine which patients will truly benefit from the addition of LH.
With a significant growth shown by the Clinical Trials market in India in the recent past, our next review article on randomization methods, use of online statistical computing web programming, and other issues related to randomization should be of great interest and will really benefit our readers and those interested in publishing their data.
Improving the outcome of In Vitro Fertilization and Embryo Transfer is of paramount importance to every infertility specialist. Nalini Mahajan and Ila Gupta have presented their study of a simple surgical approach to refashion the cervical canal, with the aim of improving the ease of Embryo Transfer in the subsequent IVF cycle, in those patients who have had a difficult treatment earlier. The study has demonstrated extremely good results with a 100% success in the ease of embryo transfer and a 46.5% pregnancy rate. Keeping in mind the improvement in pregnancy rate the authors believe that difficult embryo transfers could play a part in the failure of IVF.
Shankarkumar Umapathy et al. of the National Institute of Immunohematology, Mumbai, present their original article on the role of anti-HLA cytotoxic antibodies in recurrent spontaneous pregnancy loss. The authors believe that the incidence of high anti-HLA antibodies in recurrent spontaneous abortion women during the early weeks of gestation may explain the recurrent pregnancy loss; however, the etiology and treatment of recurrent miscarriage continue to remain enigmatic.
Pikee Saxena and group have shown that the 'Two-hour post-glucose insulin level' is an effective indicator of Insulin Resistance. It can be used as a cost-effective, convenient, and reliable indicator to diagnose insulin resistance, which holds the key to the pathogenesis of the polycystic ovary syndrome.
A study conducted at the Feinberg School of Medicine has compared the thaw survival, implantation, and live birth rates from cryopreserved zygotes, embryos, and blastocysts, and has shown that growing embryos to the blastocyst stage, prior to cryopreservation, is associated with fewer frozen embryos, but does not appear to compromise the patients' chance of achieving pregnancy.
As always, we close this issue with a few interesting case reports, one of which present a series of two cases of ovarian torsion, aptly titled, 'Missing the diagnosis means losing the ovary,' because of the frequency in which the diagnosis is often missed. The report is a gentle nudge to treat with suspicion and correctly evaluate the acute onset of abdominal pain in any female undergoing infertility treatment, to avoid losing the ovary.
There is also a case report on endometrial regeneration with the use of autologous stem cells. This case report is followed by a commentary by Caroline Gargett, who is an authority on stem cells.