Journal of Human Reproductive Sciences

LETTER TO EDITOR
Year
: 2010  |  Volume : 3  |  Issue : 3  |  Page : 161-

Predictive value of human chorionic gonadotrophin in the outcome of early pregnancy achieved by assisted reproductive technology: A summative assessment


Viroj Wiwanitkit 
 Wiwanitkit House, Bangkhae, Bangkok - 10160, Thailand

Correspondence Address:
Viroj Wiwanitkit
Wiwanitkit House, Bangkhae, Bangkok 10160
Thailand




How to cite this article:
Wiwanitkit V. Predictive value of human chorionic gonadotrophin in the outcome of early pregnancy achieved by assisted reproductive technology: A summative assessment.J Hum Reprod Sci 2010;3:161-161


How to cite this URL:
Wiwanitkit V. Predictive value of human chorionic gonadotrophin in the outcome of early pregnancy achieved by assisted reproductive technology: A summative assessment. J Hum Reprod Sci [serial online] 2010 [cited 2020 May 25 ];3:161-161
Available from: http://www.jhrsonline.org/text.asp?2010/3/3/161/74165


Full Text

Sir,

Prediction of the early pregnancy achieved by assisted reproductive technology is an important practice in the field. There are several ways to predict. Using of blood tests is an important approach. The use of human chorionic gonadotrophin (hCG) level determination is a test of interest. There are some previous reports on using this specific test for this prediction purpose. Here, the author performed a summative analysis to assess the value of human chorionic gonadotrophin (hCG). The author performed a retrospective literature search on this specific topic to find published papers in PubMed and Scopus. The derived 3 publications on 810 cases are extracted for data on diagnostic properties and summative assessment was done. [1],[2],[3] Indeed, there are two other publications on this area that are excluded. One is due to the different period of hCG measurement from other published papers (on the second week) [4] and the other is due to lack of English text. [5] Based on this assessment, the summative sensitivity and specificity for prediction of viable pregnancy are equal to 85.7 and 72.4%, respectively. For differentiation between single and multiple pregnancies in viable group, the summative sensitivity and specificity for prediction of viable pregnancy are equal to 84.3 and 79.2%. Based on this appraisal, it can be seen that hCG measurement gives only fair diagnostic property for determining the outcome of early pregnancy achieved by assisted reproductive technology.

References

1Sereepapong W, Suwajanakorn S, Pruksananonda K, Boonkasemsanti W, Virutamasen P. Predictive value of human chorionic gonadotrophin in the outcome of early pregnancy achieved by assisted reproductive technology. J Med Assoc Thai 2002;85:S447-54.
2Schmidt LL, Asch RH, Frederick JL, Rojas FJ, Stone SC, Balmaceda JP. The predictive value of a single beta human chorionic gonadotrophin in pregnancies achieved by assisted reproductive technology. Fertil Steril 1994;62:333-8.
3Heiner JS, Kerin JF, Schmidt LL, Wu TC. Can a single, early quantitative human chorionic gonadotrophin measurement in an in vitro fertilization-gamete intrafallopian transfer program predict pregnancy outcome? Fertil Steril 1992;58:373-7.
4Legro RS, Paulson RJ, Lobo RA, Sauer MV. Association of early beta-human chorionic gonadotrophin values with pregnancy wastage and multiple implantation in a donor oocyte programme. Hum Reprod 1995;10:3293-6.
5Hauzman E, Murber A, Fancsovits P, Papp Z, Urbancsek J. Use of biochemical markers to predict the outcome of pregnancies conceived by in vitro fertilization. Orv Hetil 2006;147:1409-20.