Journal of Human Reproductive Science
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ORIGINAL ARTICLE Table of Contents   
Year : 2020  |  Volume : 13  |  Issue : 1  |  Page : 46-50
Impact of serum human chorionic gonadotropin and luteinizing hormone receptor expression to oocyte maturation rate: A study of controlled ovarian stimulation


1 Department of Obstetrics and Gynecology, Faculty of Medicine, University of Syiah Kuala, Banda Aceh; Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Indonesia
2 Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia; Human Reproductive Infertility and Family Planning, Indonesian Medical Education and Research Institute; Yasmin IVF Clinic, Dr. Cipto Mangunkusumo General Hospital, Central Jakarta, Indonesia
3 Department of Obstetrics and Gynecology, Faculty of Medicine, University of Syiah Kuala, Banda Aceh, Indonesia
4 Southeast Asia Ministers of Education Regional Centre for Food and Nutrition – Pusat Kajian Gizi Regional, University of Indonesia, Central Jakarta, Indonesia
5 Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia; Human Reproductive Infertility and Family Planning, Indonesian Medical Education and Research Institute, Central Jakarta, Indonesia

Correspondence Address:
Prof. Budi Wiweko
Indonesian Medical Education and Research Institute, Salemba Raya No. 6 Street, Central Jakarta 10430
Indonesia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jhrs.JHRS_131_19

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Background: Few studies have assessed the impact of serum human chorionic gonadotropin (hCG) levels before oocyte retrieval and luteinizing hormone receptor (LHR) mRNA expression. Aims: The objective was to assess the correlations between serum hCG levels at 12-h posttrigger granulosa cell LHR mRNA expression during the in vitro fertilization (IVF) cycle with oocyte maturation rate and to determine the cutoff level of serum hCG at 12-h posttrigger. Settings and Design: A cross-sectional was conducted for this study at the IVF center of Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia. Materials and Methods: Recombinant follicle-stimulating hormone was used on day 2 of the menstrual cycle with multiple doses of a gonadotropin-releasing hormone antagonist. Recombinant hCG was used to trigger ovulation. At 12-h posttrigger, hCG serum levels were measured using an enzyme-linked immunosorbent assay. Statistical Analysis: Pearson's correlation coefficient was used to evaluate the correlation between oocyte maturation rates, serum hCG levels, and LHR mRNA levels. Cutoff values were determined using a receiver operating characteristic (ROC) curve. Results: Serum hCG levels were positively correlated (r = 0.467;P < 0.01), and LHR mRNA expression was weakly correlated (r = 0.073; P = 0.701) with oocyte maturation. The cutoff of serum hCG for a high maturation rate was 77 mIU/mL, with an area under the ROC curve of 0.765 (95% confidence interval: 0.598–0.939) andP < 0.001. Conclusion: Oocyte maturation is correlated with serum hCG levels with 77 mIU/mL as the cutoff point for oocyte retrieval.


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