Journal of Human Reproductive Science
Home Ahead of Print Current Issue Archives
   Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size    Users online: 1752


 
ORIGINAL ARTICLE Table of Contents   
Year : 2019  |  Volume : 12  |  Issue : 3  |  Page : 204-209
Role of oxidative stress and antioxidants in male infertility: An interventional study


1 Department of Obstetrics and Gynaecology, JIPMER, Puducherry, India
2 Department of Biochemistry, JIPMER, Puducherry, India

Correspondence Address:
Dr. Ganeswar Barik
Department of Obstetrics and Gynaecology, JIPMER, Puducherry - 605 006
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jhrs.JHRS_135_18

Rights and Permissions

Aims: The study aims, in infertile men, (i) to assess oxidative stress parameters in semen plasma and (ii) to study the effect of antioxidants in those with abnormal semen parameters. Settings and Design: This was an interventional study. Population: Ninety men attending and infertility clinic in a tertiary center were enrolled in the study. Materials and Methods: The present study was conducted in the departments of obstetrics and gynecology and biochemistry in a tertiary center. Ethical approval was obtained from the institute ethics subcommittee, and the study was conducted between July 2014 and July 2016. The study was conducted on two groups of 45 men with normal semen parameters in group 1 and 45 men with abnormal semen parameters in group 2. Results: Malondialdehyde (MDA) value was higher in men with abnormal semen parameters, which was statistically significant. The total antioxidant assay was higher in men with abnormal semen parameters, which was not statistically significant. Oxidative stress index (OSI) value was higher in men with normal semen parameters, which was not statistically significant. After 90 days of antioxidants therapy to men with abnormal semen parameters, MDA value decreased, total antioxidant assay increased, and OSI value decreased, which were statistically significant. Semen parameters such as sperm concentration, motility, and normal morphology improved after 90 days of antioxidant therapy, which were statistically significant. Conclusions: Oxidative stress is increased in men with abnormal semen parameters. Antioxidant therapy improves sperm concentration and motility and decreases oxidative stress in the semen plasma.


[FULL TEXT] [PDF]*
Print this article  Email this article
    

  Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
   Citation Manager
  Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed500    
    Printed26    
    Emailed0    
    PDF Downloaded63    
    Comments [Add]    

Recommend this journal