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CASE REPORT  
Year : 2018  |  Volume : 11  |  Issue : 2  |  Page : 198-201
 

Pregnancy through assisted reproductive technology in a patient with thoracic endometriosis syndrome


Gyneac & IVF, JK Women Hospital, Dombivli, Nirmiti Fertility and IVF Centre, Dombivli, Maharashtra, India

Date of Web Publication1-Aug-2018

Correspondence Address:
Dr. S Krishnakumar
JK Women Hospital, Maitri Raghukul, Shaheed Bhagat Singh Road, Dombivli (East), Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jhrs.JHRS_133_17

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   Abstract 


Extrapelvic endometriosis is known to be difficult to diagnose. Appropriate management in an infertile patient with extrapelvic endometriosis is not only difficult but also not well established. This case report describes a patient with thoracic endometriosis syndrome who was managed successfully for controlling her pleural endometriosis and achieving a pregnancy through assisted reproductive technology (ART).


Keywords: Endometriosis, pleurodesis, thoracic endometriosis syndrome, video-assisted thoracoscopy


How to cite this article:
Krishnakumar S, Krishnakumar R, Hiwale S. Pregnancy through assisted reproductive technology in a patient with thoracic endometriosis syndrome. J Hum Reprod Sci 2018;11:198-201

How to cite this URL:
Krishnakumar S, Krishnakumar R, Hiwale S. Pregnancy through assisted reproductive technology in a patient with thoracic endometriosis syndrome. J Hum Reprod Sci [serial online] 2018 [cited 2020 Apr 8];11:198-201. Available from: http://www.jhrsonline.org/text.asp?2018/11/2/198/238209





   Introduction Top


Endometriosis characterized by the presence of functional endometrial tissue outside the uterus affects 5%–15% of women during their reproductive years.[1] Although usually confined to the pelvis, endometriosis is also known to occur in the extrapelvic organs or tissues; ectopic endometrium has been found in the umbilicus, abdominal scars, breasts, extremities, pleural cavity, and lung.[2],[3],[4] Although the symptomatology of extrapelvic endometriosis is always coordinated to the menstrual cycle, this is not directly apparent in all patients and diagnosis is notoriously difficult.[5]

Here, we present a case of a patient who presented with subfertility and during workup was diagnosed to have thoracic endometriosis syndrome (TES), which was managed successfully with in vitro fertilization-embryo transfer (IVF-ET), resulting in pregnancy and delivery.


   Case Report Top


A 29-year-old female married for 4 years, presented with subfertility, with no menstrual complaints. All the basic investigations of the couple were normal, including folliculometry. She never gave a history suggestive of endometriosis or other pelvic pathology. Hence, she was advised for a diagnostic hysterolaparoscopy in November 2014. During the routine preoperative workup, an X-ray chest done in the immediate postmenstrual phase showed right-sided hydropneumothorax [Figure 1]. Hence, the surgery was postponed and reference was made to a chest physician, and on his advice, a computed tomography (CT) chest was done. The same revealed moderate hydropneumothorax with passive consolidation in the right upper and middle lobe with mild shift of mediastinum to the left [Figure 2]. The patient had occasional dry cough, but there was no history of fever, breathlessness, or weight loss, excepting right-sided chest and shoulder pain. A provisional diagnosis of Koch's was made by the treating chest physician, and the patient was started on anti-Koch's treatment. The patient was started on anti Koch's treatment on November 25, 2014, empirically. However, within 2 weeks of the treatment, the patient developed side effects of the AKT, and her liver enzymes were deranged. The patient discontinued the treatment and was referred for a second opinion for the same. She was subjected to bronchoscopy which revealed a mildly inflamed right upper lobe bronchus. The bronchial and alveolar lavage was negative for tuberculosis mycobacteria growth indicator tube and also negative for culture. Pleural tapping fluid as also subjected to the same test which also was negative. Adenosine deaminase of the pleural fluid was also negative. Both the fluid was also sent for GeneXpert, which was also not informative. A repeat CT (December 20, 2014) chest revealed the same findings, and hence, an intracostal drainage was inserted [Figure 3]. When the drain was in situ, the patient had menstruation with complaints of chest pain in the right side of the chest and the drain tube had more blood, which clinched the diagnosis of “catamenial pneumothorax.” The patient was subjected to video-assisted thoracoscopy (VATS) with bronchoscopy on January 28, 2015, in which ectopic endometrial tissues were seen over pleura, lung, as well as parts of diaphragm, were subjected to biopsy and sent for histopathology and culture, and were cauterized. Pneumatocele was identified on the right lobe, for which staples were applied. The histopathology confirmed pleural endometriosis. The tissue was subjected to immunohistochemistry which confirmed the tissue to be positive for estrogen receptor, progesterone receptor, CD-10 – consistent with pleural endometriosis [Figure 4] and [Figure 5]. As per the patient's desire, she was subjected to pleurodesis with steritalc and was put on injection leuprolide for 6 months. This gave her good relief from right-sided chest pain with amenorrhea for 9 months. The patient was monitored with a series of chest X-rays and CT scans. Serum CA-125 was not performed in this patient.
Figure 1: Right hydropneumothorax

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Figure 2: Computed tomography chest

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Figure 3: (a) International Classification of Diseases - lateral view. (b) International Classification of Diseases

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Figure 4: Histopathology report

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Figure 5: Immunohistochemical report

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The patient returned for infertility treatment in April 2016. Hysteroscopy with uterine septum resection (1–1.5 cm fundal septum – cut with scissors) was carried out on May 26, 2016. Laparoscopy was avoided as the patient had persistent right pleural effusion [Figure 6] (decreased than before). After detailed counseling, including all options, the couple wished to undergo self-stimulation and transfer. Patient's anti-Müllerian hormone was 1.65. The patient was started on IVF antagonist protocol in July 2016 with recombinant follicle-stimulating hormone 225 i.u. daily from day 2 of menstrual cycle. Ovum pick up was done on July 25, 2016, and seven oocytes were retrieved. Six embryos obtained on day 3 (3–8 cell A, 2–8 cell B, 1–8 cell C) and the embryos were electively cryopreserved. The patient received leuprolide depot for one cycle, and frozen embryo was planned in the next month with estradiol valerate 6 mg/day, from the 3rd day of cycle. After 12 days of estradiol valerate, once the endometrium was satisfactory, progesterone support was given and three embryos (2 Grade A, 1 Gr B) were transferred on August 24, 2016.
Figure 6: Persisting right pleural effusion

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The patient conceived in the same cycle and was followed up closely throughout the 9 months of pregnancy, which was uneventful. At 36 weeks of gestation, the patient presented with acute urinary retention and elective cesarean section was done on April 19, 2017, and a male child weighing 2.4 kg was delivered. Uterine surface had endometriotic blebs with increased vascularity [Figure 7]. The patient was discharged on day 6 of delivery. Lactation was also well established and has been encouraged to continue breastfeeding till at least 1-year postpartum.
Figure 7: Intraoperative findings

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An X-ray chest was taken 3 weeks postpartum [Figure 8].
Figure 8: X-ray chest postoperative

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   Discussion Top


TES is a challenging clinical entity. A high index of clinical suspicion is of paramount importance as both diagnosis and treatment may often be delayed for years. The present case had an important feature that the patient never gave any history suggestive of pelvic endometriosis, such as dysmenorrhea and dyspareunia. The detection of catamenial pneumothorax with the intercostal drainage during her menstrual cycle led to the diagnosis of pulmonary endometriosis, which in this patient was mostly only pleural and on the right side. Literature review does suggest that pleural endometriosis is more frequent on the right side,[6] as seen in this patient. Most of the cases of pleural endometriosis are associated with severe pelvic endometriosis [7] though this patient never complained about it, and the presence was detected only at the time C-section. The literature is still inconclusive about the best treatment strategy in the presence of TES in infertile young patients. Pleurodesis, especially in younger patients, should always be carried out concomitantly with VATS exploration. This way, an accurate diagnosis and treatment can be instituted and recurrences avoided. In older women and those not desirous of pregnancy, hysterectomy and bilateral salpingo-oophorectomy (BSO) is the treatment of last resort when other options have failed. Hence, a multidisciplinary approach by thoracic surgeon and gynecologist carries the highest chance of making an accurate diagnosis and providing the appropriate treatment strategies,[8] as seen in this case. Retrospectively, the decision to plan IVF-ET was the right choice for this patient and interestingly during the stimulation for IVF and subsequent transfer, and 9 months of pregnancy, the patient did not have any deterioration of the disease.

Literature review

To date, data are limited on the association between pelvic endometriosis and fertility status in patients with TES. In a recent series (2017) of 16 patients of TES by Ottolina et al.,[9] the study supported the presence of a strong association between catamenial pneumothorax and pelvic endometriosis. Pelvic endometriosis was diagnosed in 9 (56.3%) of the patients with TES. However, six patients did not undergo laparoscopic procedure to confirm or exclude the disease. Seven of the affected patients (77.8%) had moderate-to-severe disease (Stage III–IV), four conceived spontaneously after laparoscopic surgery, and all patients who did not have pelvic endometriosis conceived spontaneously. Although the study concludes that women affected by TES should be reassured about their childbearing capacity, a large study should be undertaken to definitely clarify this aspect.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient has given her consent for her images and other clinical information to be reported in the journal. The patient understands that name and initial will not be published and due efforts will be made to conceal identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Schuld J, Justinger C, Wagner M, Bohle RM, Kollmar O, Schilling MK, et al. Bronchobiliary fistula: A rare complication of hepatic endometriosis. Fertil Steril 2011;95:804.e15-8.  Back to cited text no. 1
    
2.
Hilaris GE, Payne CK, Osias J, Cannon W, Nezhat CR. Synchronous rectovaginal, urinary bladder, and pulmonary endometriosis. JSLS 2005;9:78-82.  Back to cited text no. 2
    
3.
Visouli AN, Darwiche K, Mpakas A, Zarogoulidis P, Papagiannis A, Tsakiridis K, et al. Catamenial pneumothorax: A rare entity? Report of 5 cases and review of the literature. J Thorac Dis 2012;4 Suppl 1:17-31.  Back to cited text no. 3
    
4.
Simoglou C, Zarogoulidis P, Machairiotis N, Porpodis K, Simoglou L, Mitrakas A, et al. Abdominal wall endometrioma mimicking an incarcerated hernia: A case report. Int J Gen Med 2012;5:569-71.  Back to cited text no. 4
    
5.
Huang H, Li C, Zarogoulidis P, Darwiche K, Machairiotis N, Yang L, et al. Endometriosis of the lung: Report of a case and literature review. Eur J Med Res 2013;18:13.  Back to cited text no. 5
    
6.
Korom S, Canyurt H, Missbach A, Schneiter D, Kurrer MO, Haller U, et al. Catamenial pneumothorax revisited: Clinical approach and systematic review of the literature. J Thorac Cardiovasc Surg 2004;128:502-8.  Back to cited text no. 6
    
7.
Joseph J, Sahn SA. Thoracic endometriosis syndrome: New observations from an analysis of 110 cases. Am J Med 1996;100:164-70.  Back to cited text no. 7
    
8.
Nezhat C, Nicoll LM, Bhagan L, Huang JQ, Bosev D, Hajhosseini B, et al. Endometriosis of the diaphragm: Four cases treated with a combination of laparoscopy and thoracoscopy. J Minim Invasive Gynecol 2009;16:573-80.  Back to cited text no. 8
    
9.
Ottolina J, De Stefano F, Viganò P, Ciriaco P, Zannini P, Candiani M, et al. Thoracic endometriosis syndrome: Association with pelvic endometriosis and fertility status. J Minim Invasive Gynecol 2017;24:461-5.  Back to cited text no. 9
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6], [Figure 7], [Figure 8]



 

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