Journal of Human Reproductive Science
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ORIGINAL ARTICLE Table of Contents   
Year : 2015  |  Volume : 8  |  Issue : 4  |  Page : 224-229
Prevalence and role of antithrombin III, protein C and protein S deficiencies and activated protein C resistance in Kosovo women with recurrent pregnancy loss during the first trimester of pregnancy


1 Institute of Pathophysiology, Faculty of Medicine, University of Prishtina; Department of Hemostasis and Thrombosis, National Blood Transfusion Center of Kosovo, Prishtina, Kosovo
2 Clinic of Gynecology and Obstetrics, University Clinical Center of Kosovo, Prishtina, Kosovo
3 Department of Hemostasis and Thrombosis, National Blood Transfusion Center of Kosovo, Prishtina, Kosovo
4 Clinic of Neurosurgery, Faculty of Medicine, University of Prishtina, Prishtina 10000, Kosovo

Correspondence Address:
Agon Mekaj
Faculty of Medicine, University of Prishtina. Rrethi i spitalit p.n. Prishtina 10000
Kosovo
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-1208.170407

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Context: Several studies have reported that thrombophilia is responsible for recurrent pregnancy loss (RPL). AIMS: The aim of this study was to evaluate the prevalence and role of inherited thrombophilia in early pregnancy loss, specifically in the first trimester. Materials and Methods: A total of 104 women (patients) with a history of two or more miscarriages during the first trimester of pregnancy and 110 women (controls) who had experienced two or more births without a miscarriage were included in this study. In both groups, we determined the biological activities of antithrombin III (ATIII) and protein C (PC) using the chromogenic method and the biological activity of protein S (PS) and the activated protein C resistance (APCR) were examined using a clotting method. Results: In the patient group, deficiencies of ATIII, PC, and PS were detected in 3 (2.88%), 4 (3.85%), and 6 (5.77%) cases, respectively. In the control group, ATIII (0%) deficiencies were not detected, and deficiencies for PC (0.9%) and PS (0.9%) were each detected in 1 patient. APCR was detected in 9 patients (8.65%) and 4 control subjects (3.63%). Conclusion: Based on our results, we can conclude that thrombophilia is a causal factor for miscarriages in the first trimester of pregnancy, although there are the conflicting data in the literature.


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