Journal of Human Reproductive Science
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ORIGINAL ARTICLE Table of Contents   
Year : 2015  |  Volume : 8  |  Issue : 4  |  Page : 214-217
Role of Embryo Glue as a transfer medium in the outcome of fresh non-donor in-vitro fertilization cycles


Department of Obstetrics and Gynaecology, AIIMS, New Delhi, India

Correspondence Address:
Neeta Singh
Department of Obstetrics and Gynecology, Room No-3090A, Third Floor, Teaching Block, All India Institute of Medical Sciences, Ansari Nagar, New Delhi
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-1208.170398

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Background: EmbryoGlue is a hyaluronan-enriched embryo transfer (ET) medium which aids in implantation of embryos, hence, improves pregnancy rates in in-vitro fertilization-ET cycles (IVF-ET). Aim: To evaluate the role of EmbryoGlue in improving implantation and pregnancy rates. Design and Setting: A prospective case-control study conducted at assisted reproductive center of a tertiary care hospital. Method: In 42 women undergoing IVF, embryos were transferred into 50 μL of EmbryoGlue for 10 min prior to transfer inside uterine cavity. In the control group (n = 42), embryos were transferred to conventional blastocyst culture medium. Statistical analysis was performed using SPSS IBM version 19.0. Results: Clinical pregnancy rate in the study group was 7% higher than the control group. The difference, however, was not statistically significant. In addition, no improvement in implantation rates was observed in the study group. However, significant difference (P = 0.04) in clinical pregnancy rate was observed with the EmbryoGlue in patients with previous IVF failure. In the study group, 50% patients (6/12) with previous IVF failure had successful implantation, but in the control group none of the patients (0/11) with previous implantation failure could achieve pregnancy. Conclusion: It is difficult to conclude a favourable role of EmbryoGlue in IVF-ET cycles with a good prognosis. However, in patients with recurrent implantation failure, it may be considered as a useful transfer medium.


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