Journal of Human Reproductive Science
Home Ahead of Print Current Issue Archives
   Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size    Users online: 807


 
CASE REPORT Table of Contents   
Year : 2015  |  Volume : 8  |  Issue : 3  |  Page : 175-177
Successful fertilization and embryo development after spermatid injection: A hope for nonobstructive azoospermic patients


Department of Reproductive Medicine, Ridge IVF Private Limited, Delhi, India

Correspondence Address:
Geeta Goswami
Department of Reproductive Medicine, Ridge IVF Private Limited, 30, Malka Ganj Road, Jawahar Nagar, Delhi - 110 007
India
Login to access the Email id

Source of Support: Nil., Conflict of Interest: There are no conflicts of interest.


DOI: 10.4103/0974-1208.165147

Rights and Permissions

Spermatids are the earliest male germ cells with haploid set of chromosomes. Spermatid injection was introduced in human assisted reproduction for the treatment of men with non-obstructive azoospermia. Spermatozoa can be recovered in half of patients with nonobstructive azoospermia. The use of spermatids for intracytoplasmic injection (ICSI) has been proposed for cases in which no spermatozoa can be retrieved. However, there are low pregnancy rates following ICSI using round spermatids from men with no elongated spermatids or spermatozoa in their testes. The in vitroculture of immature germ cells has been proposed as a means to improve this poor outcome. Oocyte activation rarely occurs when injected with a spermatid. Therefore, spermatid injection requires use of calcium ionophores for oocyte activation which is otherwise carried out by PLC zeta from mature sperms. This is the only option available for the nonobstructive azoospermic patients to have their own biological child.


[FULL TEXT] [PDF]*
Print this article  Email this article
    

  Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
   Citation Manager
  Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2295    
    Printed39    
    Emailed0    
    PDF Downloaded79    
    Comments [Add]    

Recommend this journal