Journal of Human Reproductive Science
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CASE REPORT Table of Contents   
Year : 2015  |  Volume : 8  |  Issue : 3  |  Page : 170-174
Empty follicle syndrome: Successful pregnancy following dual trigger


Department of Reproductive Medicine, Milann - The Fertility Center, Bengaluru, Karnataka, India

Correspondence Address:
K Deepika
Department of Reproductive Medicine, Milann - The Fertility Center, No. 6/7, Kumara Krupa Road, High Grounds, Bengaluru - 560 001, Karnataka
India
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Source of Support: Nil., Conflict of Interest: There are no conflicts of interest.


DOI: 10.4103/0974-1208.165152

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Empty follicle syndrome (EFS) is an uncommon, but the frustrating complication of assisted reproductive technology with failure to obtain oocytes after an adequate ovarian response to stimulation. Most of the reported cases of EFS are drug-related problems which are actually avoidable and do not represent any potential pathology and that the risk of genuine EFS (GEFS) is much smaller than was once thought. Our case is thefirst report of a pregnancy obtained after management of GEFS with dual trigger in a gonadotropin-releasing hormone (GnRH) antagonist cycle. In this report, we present a patient who underwent two oocyte retrievals, in which no oocytes were obtained. In the third in-vitrofertilization cycle, a dual trigger with the combination of GnRH agonist and human chorionic gonadotropin yielded 11 oocytes, which led to the transfer of 2 blastocysts resulting in a live birth. Changing the treatment protocol with dual trigger brought about a successful outcome.


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