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REVIEW ARTICLE  
Year : 2012  |  Volume : 5  |  Issue : 1  |  Page : 2-6
 

Understanding implantation window, a crucial phenomenon


1 Department of Obstetrics and Gynaecology, Deen Dayal Upadhyaya Hospital, Shimla, Himachal Pradesh, India
2 Department of Obstetrics and Gynaecology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India

Date of Submission13-Mar-2012
Date of Decision13-Mar-2012
Date of Acceptance15-Mar-2012
Date of Web Publication2-Jul-2012

Correspondence Address:
Pratap Kumar
Professor, Department of Obstetrics and Gynecology, Kasturba Medical College, Manipal University, Manipal 576104, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-1208.97777

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   Abstract 

Embryo implantation is a well-defined and precise process, in which various factors come into play one after the other. There is only a specific period of time during which implantation is possible i.e. "implantation window". Selectins were proposed to have an important role in this phase to ensure suitable rolling of the blastocyst. To prevent the blastocyst from adhering to an area with poor chances of implantation, an important role is played by the repellent activity of MUC-1, which is widely expressed throughout the endometrium and, surprisingly, even increases before implantation. In particular endometrial areas, secretion of chemokines and growth factors will attract the blastocyst to landing platforms known as pinopods. These pinopods are fully developed for only 1 or 2 days and extend over the tips of the microvilli expressing the repellent MUC-1. At this stage, adhesion molecules such as integrins and cadherins intervene to ensure adhesiveness between the embryo and the endometrium.


Keywords: Cellular adhesion molecule family, decidua, implantation


How to cite this article:
Sharma A, Kumar P. Understanding implantation window, a crucial phenomenon. J Hum Reprod Sci 2012;5:2-6

How to cite this URL:
Sharma A, Kumar P. Understanding implantation window, a crucial phenomenon. J Hum Reprod Sci [serial online] 2012 [cited 2018 Jan 19];5:2-6. Available from: http://www.jhrsonline.org/text.asp?2012/5/1/2/97777


This has been retracted as the sections in the text have been directly copied from a previously published article, entitled, "Endometrial receptivity markers, the journey to successful embryo implantation," in pages 731-746, Issue 6, Vol. 12 of Human Reproduction Update.







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