Journal of Human Reproductive Science
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LETTER TO EDITOR  
Year : 2011  |  Volume : 4  |  Issue : 3  |  Page : 157
 

Discrepancy in the results of Y chromosome microdeletions in an Iranian population


1 Department of Reproductive Genetics and Biotechnology, Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
2 Department of Reproductive Genetics and Biotechnology, Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR; Genetic Research Center, University of Social Welfare and Rehabilitation Science, Tehran, Iran

Date of Web Publication25-Jan-2012

Correspondence Address:
Kioomars Saliminejad
Avicenna Research Institute, Shahid Beheshti University, PO Box 19615 1177, Evin, Tehran
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-1208.92295

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How to cite this article:
Saliminejad K, Khorshid HK. Discrepancy in the results of Y chromosome microdeletions in an Iranian population. J Hum Reprod Sci 2011;4:157

How to cite this URL:
Saliminejad K, Khorshid HK. Discrepancy in the results of Y chromosome microdeletions in an Iranian population. J Hum Reprod Sci [serial online] 2011 [cited 2019 Jul 18];4:157. Available from: http://www.jhrsonline.org/text.asp?2011/4/3/157/92295


Sir,

A few studies of the Y chromosome microdeletions have been performed among Iranian infertile males. Because of the high frequency of microdeletions of the Y chromosome reported by Malekasgar and Mombaini, [1] we reviewed with a great interest the related paper. They found microdeletions in 51.6% (16/31) of azoospermic patients and 52.6% (10/19) of severe oligozoospermic men in South of Iran. [1] According to their results, the incidence of Y microdeletions was much higher than the reported frequency in other countries. They reported four azoo/oligozoospermic patients with the deletion of only one of the two markers sY254 or sY255 in these men. [1]

The two markers sY254 and sY255 are specific for the human DAZ genes, which is present in four copies arranged in two clusters, each comprising an inverted pair of DAZ genes. [2] The absence of both STSs indicates the deletion of the entire AZFc region, which removes all copies of the DAZ genes. According to current knowledge, the deletion of only one of these two STSs is impossible and should be always regarded as a methodological mistake. The deletion of individual copies of the DAZ genes is possible but cannot be detected with PCR or multiplex PCR. [3] For the detection of Y chromosome microdeletions in AZFa, AZFb, and AZFc regions, there are validated guidelines endorsed by the European Academy of Andrology (EAA) and the European Molecular Genetics Quality Network (EMQN). [3] This protocol could detect up to 95% of all reported AZF microdeletions; [3] however, Malekasgar and Mombaini did not use this guideline in the screening of infertile men in South of Iran.

 
   References Top

1.Malekasgar AM, Mombaini H. Screening of Y chromosome microdeletions in Iranian infertile males. J Hum Reprod Sci 2008;1:2-9.  Back to cited text no. 1
[PUBMED]  Medknow Journal  
2.Saxena R, de Vries JW, Repping S, Alagappan RK, Skaletsky H, Brown LG, et al. Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome. Genomics 2000;67:256-67.  Back to cited text no. 2
[PUBMED]  [FULLTEXT]  
3.Simoni M, Bakker E, Krausz C. EAA/EMQN best practice guidelines for molecular diagnosis of y-chromosomal microdeletions. State of the art 2004. Int J Androl 2004;27:240-9.  Back to cited text no. 3
[PUBMED]  [FULLTEXT]  



This article has been cited by
1 Discrepancy in the Frequency of Y Chromosome Microdeletions Among Iranian Infertile Men with Azoospermia and Severe Oligozoospermia
Kioomars Saliminejad,Mohammad Reza Sadeghi,Koorosh Kamali,Naser Amirjannati,Haleh Soltanghoraee,Hamid Reza Khorram Khorshid
Genetic Testing and Molecular Biomarkers. 2012; 16(8): 931
[Pubmed] | [DOI]
2 Discrepancy in the frequency of y chromosome microdeletions among iranian infertile men with azoospermia and severe oligozoospermia
Saliminejad, K. and Sadeghi, M.R. and Kamali, K. and Amirjannati, N. and Soltanghoraee, H. and Khorshid, H.R.K.
Genetic Testing and Molecular Biomarkers. 2012; 16(8): 931-934
[Pubmed]
3 Authorsę reply
Malekasgar, A.M., Mombaini, H.
# # Journal of Human Reproductive Sciences. 2011; 4(3): 157-158
[Pubmed]



 

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