Journal of Human Reproductive Science
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CASE REPORT Table of Contents   
Year : 2011  |  Volume : 4  |  Issue : 1  |  Page : 43-48
Endometrial regeneration using autologous adult stem cells followed by conception by in vitro fertilization in a patient of severe Asherman's syndrome


1 Dr. Nagori's Institute for Infertility and IVF, Ahmedabad, India
2 Stem Cure (Centre for Reproductive Medicine and Stem Cell Therapy), Ahmedabad, India

Correspondence Address:
Sonal Y Panchal
Dr. Nagori's Institute for Infertility and IVF, 2nd Floor, Kedar, Opp. Petrol Pump, Nr. Parimal Garden, Ahmedabad - 380 006
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-1208.82360

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In a woman with severe Asherman's syndrome, curettage followed by placement of intrauterine contraceptive device (IUCD) (IUCD with cyclical hormonal therapy) was tried for 6 months, for development of the endometrium. When this failed, autologous stem cells were tried as an alternative therapy. From adult autologous stem cells isolated from patient's own bone marrow, endometrial angiogenic stem cells were separated using immunomagnetic isolation. These cells were placed in the endometrial cavity under ultrasound guidance after curettage. Patient was then given cyclical hormonal therapy. Endometrium was assessed intermittently on ultrasound. On development of endometrium with a thickness of 8 mm and good vascularity, in vitro fertilization and embryo transfer was done. This resulted in positive biochemical pregnancy followed by confirmation of gestational sac, yolk sac, and embryonic pole with cardiac activity on ultrasound. Endometrial angiogenic stem cells isolated from autologous adult stem cells could regenerate injured endometrium not responding to conventional treatment for Asherman's syndrome.


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