Journal of Human Reproductive Science
Home Ahead of Print Current Issue Archives
   Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size    Users online: 1504


 
ORIGINAL ARTICLE Table of Contents   
Year : 2011  |  Volume : 4  |  Issue : 1  |  Page : 17-19
Role of anti-human lymphocyte culture cytotoxic antibodies in recurrent spontaneous pregnancy loss women


National Institute of Immunohaematology, KEM Hospital Campus, Mumbai, Maharashtra, India

Correspondence Address:
Shankarkumar Umapathy
National Institute of Immunohaematology,13th Floor, KEM Hospital,Parel, Mumbai - 400012, Maharashtra
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-1208.82354

Rights and Permissions

Background : Recurrent spontaneous pregnancy (RSA) is defined as a sequence of three or more consecutive spontaneous abortions. One of the major causes of RSA is immunological where alloimmune antibodies develop towards human leucocyte antigen (HLA) antigens. Earlier research had suggested that anti-HLA antibodies are produced in normal women; studies have been reported that normal pregnant women develop anti-HLA antibodies, mostly after 20-28 weeks of gestation. Aim : To evaluate the role of anti-HLA antibodies in RSA patients Materials and Methods : A total of 80 randomly selected couples with unexplained three or more RSA and control group of 50 normal pregnant women were screened for anti-HLA A and B antibodies. The anti-HLA antibodies were analyzed following the standard two-stage NIH microlymphocytotoxicity assay. Results : In our study group a high frequency of anti-HLA antibodies among women with RSA (26.25%) was detected compared to normal pregnant women (8.0%). Most of the sera showed HLA-A and HLA-B antibodies which had high titer, up to a dilution of 1: 4096. Conclusion : This incidence of high anti-HLA antibodies in RSA women during early weeks of gestation may explain the recurrent pregnancy loss.


[FULL TEXT] [PDF]*
Print this article  Email this article
    

  Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
   Citation Manager
  Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2475    
    Printed169    
    Emailed0    
    PDF Downloaded155    
    Comments [Add]    
    Cited by others 3    

Recommend this journal