Journal of Human Reproductive Science
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CASE REPORT Table of Contents   
Year : 2010  |  Volume : 3  |  Issue : 1  |  Page : 35-37
Congenital malformation of fetus in a pregnancy following spontaneous ovulation in a case of premature ovarian failure


Department of Reproductive Medicine, GG Hospital, Fertility Research Centre, Chennai, Tamilnadu, India

Correspondence Address:
Priya Selvaraj
GG Hospital, Fertility Research Centre, 6E Nungambakkam High Road, Chennai, Tamilnadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-1208.63121

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Premature ovarian failure (POF), that is, amenorrhea before 40 years of age can be attributed to a variety of etiologies. Approximately 1% of women before 30 years are diagnosed with POF. Spontaneous ovulation leading to pregnancy in POF is even a rarer entity. We report a case where congenital malformations were diagnosed in a fetus following spontaneous ovulation in a case of POF. A 33-year-old woman presented to our center with primary infertility. On complete work up, she was diagnosed with POF and conceived with hormone replacement therapy and donor oocyte program. She delivered a healthy female baby through caesarean section. The patient reviewed later with amenorrhea of 40 days and pregnancy was confirmed. However, during antenatal follow-up congenital anomalies in fetus were diagnosed sonographically. The decision for termination of pregnancy was taken. To conclude, we recommend large-scale retrospective analysis that would define medical guidelines in cases of pregnancy following spontaneous ovulation in POF.


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