Journal of Human Reproductive Science
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ORIGINAL ARTICLE Table of Contents   
Year : 2008  |  Volume : 1  |  Issue : 1  |  Page : 19-24
HLA allele associations in idiopathic recurrent spontaneous abortion patients from India


1 HLA Department, Institute of Immunohaematology, 13th Floor, KEM Hospital, Parel, Mumbai, India
2 Department of Obstetrics and Gynaecology, KEM Hospital, Parel, Mumbai - 400 012, Maharashtra, India

Correspondence Address:
U Shankarkumar
13th Floor, KEM Hospital, Parel Mumbai - 400 012
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-1208.39592

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Background : Rejection of semiallogenic foetus in recurrent spontaneous abortion (RSA) has been postulated to be a consequence of genetic and immunological phenomena. Aim: To evaluate the role of human leukocyte antigen (HLA) alleles in RSA in Indian couples. Settings and Design : A case-control study. Materials and Methods : Eighty-one randomly selected couples with unexplained three or more RSAs and a control group of 97 couples with live birth belonging to the same ethnic background, referred to the Gynaecology Department, KEM Hospital were included in the case-control study. Serological HLA A and B typing was done followed by molecular subtypes, defined using PCR-SSOP technique for HLA A, B, and C in 40 couples and DRB1* and DQB1* in 28 couples which were then compared with appropriate case 46 and 88 controls. Results : Serologically A3 (15.43% vs . 4.43%; odds ratio (OR) = 4.34; P = 0.0002) and B17 (25.3% vs . 11.34%; OR = 3.49; P = 0.0001) were increased. Haplotype A1-B17 was significantly increased. Molecular subtyping revealed that A*030102 (11.25% vs . 4.34%; OR = 3.00; P = 0.07), B*5701 (11.25% vs . 1.08%; OR = 13.10; P = 0.003), Cw*120201 (25% vs . 4.34%; OR = 10.50; P = 2.05E-05), HLA DRB1*030101 (17.85% vs . 3.40%; OR = 7.6; P = 0.0001), DRB1*150101 (32.14% vs . 13.63%; OR = 4.8; P = 0.0003), and DQB1*060101 (35.71% vs . 29.34%; OR = 2.3; P = 0.004) were significantly increased in patients. A differential association was noticed when compared with reported world RSA patients. Conclusion: The HLA alleles A*030101, B*5701, Cw*120201, DRB1*030101, and DRB1*150101 as well as their associated ancestral haplotype may play a significant role in development of RSA in India.


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